Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians
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Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians. / Rasmussen, Søren K; Urhammer, Søren A; Berglund, Lars Erik; Jensen, Jan N; Hansen, Lars; Echwald, Søren Morgenthaler; Borch-Johnsen, Knut; Horikawa, Yukio; Mashima, Hirosato; Lithell, Hans; Cox, Nancy J; Hansen, Torben; Bell, Graeme I; Pedersen, Oluf.
In: Diabetes, Vol. 51, No. 12, 2002, p. 3561-7.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians
AU - Rasmussen, Søren K
AU - Urhammer, Søren A
AU - Berglund, Lars Erik
AU - Jensen, Jan N
AU - Hansen, Lars
AU - Echwald, Søren Morgenthaler
AU - Borch-Johnsen, Knut
AU - Horikawa, Yukio
AU - Mashima, Hirosato
AU - Lithell, Hans
AU - Cox, Nancy J
AU - Hansen, Torben
AU - Bell, Graeme I
AU - Pedersen, Oluf
PY - 2002
Y1 - 2002
N2 - Variations in the calpain-10 gene (CAPN10) have been identified among Mexican-Americans, and an at-risk haplotype combination (112/121) defined by three polymorphisms, UCSNP-43, -19, and -63, confers increased risk of type 2 diabetes. Here we examine the three polymorphisms in 1,594 Scandinavian subjects, including 409 type 2 diabetic patients, 200 glucose-tolerant control subjects, 322 young healthy subjects, 206 glucose-tolerant offspring of diabetic patients, and 457 glucose-tolerant 70-year-old men. The frequency of the 112/121 combination was not significantly different in 409 type 2 diabetic subjects compared with 200 glucose-tolerant control subjects (0.06 vs. 0.05; odds ratio 1.32 [95% CI 0.58-3.30]). In glucose-tolerant subjects, neither the single-nucleotide polymorphisms individually nor the 112/121 combination were associated with alterations in plasma glucose, serum insulin, or serum C-peptide levels at fasting or during an oral glucose tolerance test, estimates of insulin sensitivity, or glucose-induced insulin secretion. In conclusion, the frequency of the 112/121 at-risk haplotype of CAPN10 is low among Scandinavians and we were unable to demonstrate significant associations between the CAPN10 variants and type 2 diabetes, insulin resistance, or impaired insulin secretion.
AB - Variations in the calpain-10 gene (CAPN10) have been identified among Mexican-Americans, and an at-risk haplotype combination (112/121) defined by three polymorphisms, UCSNP-43, -19, and -63, confers increased risk of type 2 diabetes. Here we examine the three polymorphisms in 1,594 Scandinavian subjects, including 409 type 2 diabetic patients, 200 glucose-tolerant control subjects, 322 young healthy subjects, 206 glucose-tolerant offspring of diabetic patients, and 457 glucose-tolerant 70-year-old men. The frequency of the 112/121 combination was not significantly different in 409 type 2 diabetic subjects compared with 200 glucose-tolerant control subjects (0.06 vs. 0.05; odds ratio 1.32 [95% CI 0.58-3.30]). In glucose-tolerant subjects, neither the single-nucleotide polymorphisms individually nor the 112/121 combination were associated with alterations in plasma glucose, serum insulin, or serum C-peptide levels at fasting or during an oral glucose tolerance test, estimates of insulin sensitivity, or glucose-induced insulin secretion. In conclusion, the frequency of the 112/121 at-risk haplotype of CAPN10 is low among Scandinavians and we were unable to demonstrate significant associations between the CAPN10 variants and type 2 diabetes, insulin resistance, or impaired insulin secretion.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Calpain
KW - Chromosomes, Human, Pair 2
KW - Cohort Studies
KW - Control Groups
KW - Diabetes Mellitus, Type 2
KW - European Continental Ancestry Group
KW - Female
KW - Genetic Predisposition to Disease
KW - Genetic Variation
KW - Glucose
KW - Haplotypes
KW - Humans
KW - Insulin
KW - Insulin Resistance
KW - Male
KW - Middle Aged
KW - Phenotype
KW - Polymorphism, Genetic
KW - Scandinavia
M3 - Journal article
C2 - 12453914
VL - 51
SP - 3561
EP - 3567
JO - Diabetes
JF - Diabetes
SN - 0012-1797
IS - 12
ER -
ID: 38457830