Universal thermodynamic bounds on the Fano factor of discriminatory networks with unidirectional transitions
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Universal thermodynamic bounds on the Fano factor of discriminatory networks with unidirectional transitions. / Berx, Jonas; Proesmans, Karel Josef A.
In: Europhysics Letters, Vol. 145, 51001, 15.03.2024.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Universal thermodynamic bounds on the Fano factor of discriminatory networks with unidirectional transitions
AU - Berx, Jonas
AU - Proesmans, Karel Josef A
PY - 2024/3/15
Y1 - 2024/3/15
N2 - We derive a universal lower bound on the Fano factors of general biochemical discriminatory networks involving irreversible catalysis steps, based on the thermodynamic uncertainty relation, and compare it to a numerically exact Pareto optimal front. This bound is completely general, involving only the reversible entropy production per product formed and the error fraction of the system. We then show that by judiciously choosing which transitions to include in the reversible entropy production, one can derive a family of bounds that can be fine-tuned to include physical observables at hand. Lastly, we test our bound by considering three discriminatory schemes: a multi-stage Michaelis-Menten network, a Michaelis-Menten network with correlations between subsequent products, and a multi-stage kinetic proofreading network, where for the latter application the bound is altered to include the hydrolytic cost of the proofreading steps. We find that our bound is remarkably tight.
AB - We derive a universal lower bound on the Fano factors of general biochemical discriminatory networks involving irreversible catalysis steps, based on the thermodynamic uncertainty relation, and compare it to a numerically exact Pareto optimal front. This bound is completely general, involving only the reversible entropy production per product formed and the error fraction of the system. We then show that by judiciously choosing which transitions to include in the reversible entropy production, one can derive a family of bounds that can be fine-tuned to include physical observables at hand. Lastly, we test our bound by considering three discriminatory schemes: a multi-stage Michaelis-Menten network, a Michaelis-Menten network with correlations between subsequent products, and a multi-stage kinetic proofreading network, where for the latter application the bound is altered to include the hydrolytic cost of the proofreading steps. We find that our bound is remarkably tight.
U2 - 10.1209/0295-5075/ad2d14
DO - 10.1209/0295-5075/ad2d14
M3 - Journal article
VL - 145
JO - Europhysics Letters
JF - Europhysics Letters
SN - 1286-4854
M1 - 51001
ER -
ID: 387374615