TY - JOUR

T1 - Type 1 narcolepsy is not present in 29 HPV-vaccinated individuals with subjective sleep complaints

AU - Torstensen, Eva Wiberg

AU - Brinth, Louise Schouborg

AU - Mehlsen, Jesper

AU - Kornum, Birgitte Rahbek

AU - Jennum, Poul Jørgensen

N1 - Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.

PY - 2018

Y1 - 2018

N2 - INTRODUCTION: Human papilloma virus (HPV) vaccine uptake in girls and women is dropping markedly in some countries. Concern about the presumed side effects is the commonest reason why. Reports about side effects include specific sleep complaints such as excessive daytime sleepiness, altered dream activity and periods of muscle weakness. These symptoms are commonly seen in individuals with narcolepsy type 1. We aimed to evaluate whether HPV vaccination was associated with the development of hypocretin-deficient narcolepsy.METHODS: We report the evaluation for sleep disorders, including narcolepsy, in 29 HPV-vaccinated girls and women who were submitted for evaluation of narcolepsy. All were evaluated by polysomnography and the Multiple Sleep Latency Test, and 18 individuals were also evaluated by measures of cerebrospinal fluid hypocretin-1 concentration.RESULTS: None of the 29 girls and women showed signs of narcolepsy type 1.CONCLUSION: Our results do not suggest that an association exists between HPV vaccination and the development of narcolepsy type 1.FUNDING: none.TRIAL REGISTRATION: not relevant.

AB - INTRODUCTION: Human papilloma virus (HPV) vaccine uptake in girls and women is dropping markedly in some countries. Concern about the presumed side effects is the commonest reason why. Reports about side effects include specific sleep complaints such as excessive daytime sleepiness, altered dream activity and periods of muscle weakness. These symptoms are commonly seen in individuals with narcolepsy type 1. We aimed to evaluate whether HPV vaccination was associated with the development of hypocretin-deficient narcolepsy.METHODS: We report the evaluation for sleep disorders, including narcolepsy, in 29 HPV-vaccinated girls and women who were submitted for evaluation of narcolepsy. All were evaluated by polysomnography and the Multiple Sleep Latency Test, and 18 individuals were also evaluated by measures of cerebrospinal fluid hypocretin-1 concentration.RESULTS: None of the 29 girls and women showed signs of narcolepsy type 1.CONCLUSION: Our results do not suggest that an association exists between HPV vaccination and the development of narcolepsy type 1.FUNDING: none.TRIAL REGISTRATION: not relevant.

KW - Adolescent

KW - Adult

KW - Child

KW - Denmark/epidemiology

KW - Female

KW - Humans

KW - Narcolepsy/epidemiology

KW - Orexins/cerebrospinal fluid

KW - Papillomavirus Vaccines/adverse effects

KW - Polysomnography

KW - Retrospective Studies

KW - Sleep

KW - Young Adult

M3 - Journal article

C2 - 30382019

VL - 65

JO - Danish Medical Journal

JF - Danish Medical Journal

SN - 2245-1919

IS - 11

M1 - A5510

ER -