Trends in underlying causes of death in solid organ transplant recipients between 2010 and 2020: Using the CLASS method for determining specific causes of death

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Standard

Trends in underlying causes of death in solid organ transplant recipients between 2010 and 2020 : Using the CLASS method for determining specific causes of death. / Søborg, Andreas; Reekie, Joanne; Rasmussen, Allan; Cunha-Bang, Caspar Da; Gustafsson, Finn; Rossing, Kasper; Perch, Michael; Krohn, Paul Suno; Sørensen, Søren Schwartz; Lund, Thomas Kromann; Sørensen, Vibeke Rømming; Ekenberg, Christina; Lundgren, Louise; Lodding, Isabelle Paula; Moestrup, Kasper Sommerlund; Lundgren, Jens; Wareham, Neval Ete.

In: PLoS ONE, Vol. 17, No. 7 , e0263210, 2022.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Søborg, A, Reekie, J, Rasmussen, A, Cunha-Bang, CD, Gustafsson, F, Rossing, K, Perch, M, Krohn, PS, Sørensen, SS, Lund, TK, Sørensen, VR, Ekenberg, C, Lundgren, L, Lodding, IP, Moestrup, KS, Lundgren, J & Wareham, NE 2022, 'Trends in underlying causes of death in solid organ transplant recipients between 2010 and 2020: Using the CLASS method for determining specific causes of death', PLoS ONE, vol. 17, no. 7 , e0263210. https://doi.org/10.1371/journal.pone.0263210

APA

Søborg, A., Reekie, J., Rasmussen, A., Cunha-Bang, C. D., Gustafsson, F., Rossing, K., Perch, M., Krohn, P. S., Sørensen, S. S., Lund, T. K., Sørensen, V. R., Ekenberg, C., Lundgren, L., Lodding, I. P., Moestrup, K. S., Lundgren, J., & Wareham, N. E. (2022). Trends in underlying causes of death in solid organ transplant recipients between 2010 and 2020: Using the CLASS method for determining specific causes of death. PLoS ONE, 17(7 ), [e0263210]. https://doi.org/10.1371/journal.pone.0263210

Vancouver

Søborg A, Reekie J, Rasmussen A, Cunha-Bang CD, Gustafsson F, Rossing K et al. Trends in underlying causes of death in solid organ transplant recipients between 2010 and 2020: Using the CLASS method for determining specific causes of death. PLoS ONE. 2022;17(7 ). e0263210. https://doi.org/10.1371/journal.pone.0263210

Author

Søborg, Andreas ; Reekie, Joanne ; Rasmussen, Allan ; Cunha-Bang, Caspar Da ; Gustafsson, Finn ; Rossing, Kasper ; Perch, Michael ; Krohn, Paul Suno ; Sørensen, Søren Schwartz ; Lund, Thomas Kromann ; Sørensen, Vibeke Rømming ; Ekenberg, Christina ; Lundgren, Louise ; Lodding, Isabelle Paula ; Moestrup, Kasper Sommerlund ; Lundgren, Jens ; Wareham, Neval Ete. / Trends in underlying causes of death in solid organ transplant recipients between 2010 and 2020 : Using the CLASS method for determining specific causes of death. In: PLoS ONE. 2022 ; Vol. 17, No. 7 .

Bibtex

@article{09437dc5846846ba981a573df8f26138,
title = "Trends in underlying causes of death in solid organ transplant recipients between 2010 and 2020: Using the CLASS method for determining specific causes of death",
abstract = "Monitoring specific underlying causes of death in solid organ transplant (SOT) recipients is important in order to identify emerging trends and health challenges. This retrospective cohort study includes all SOT recipients transplanted at Rigshospitalet between January 1st, 2010 and December 31st, 2019. The underlying cause of death was determined using the newly developed Classification of Death Causes after Transplantation (CLASS) method. Cox regression analyses assessed risk factors for all-cause and cause-specific mortality. Of the 1774 SOT recipients included, 299 patients died during a total of 7511 person-years of follow-up (PYFU) with cancer (N = 57, 19%), graft rejection (N = 55, 18%) and infections (N = 52, 17%) being the most frequent causes of death. We observed a lower risk of all-cause death with increasing transplant calendar year (HR 0.91, 95% CI 0.86–0.96 per 1-year increase), alongside death from graft rejection (HR 0.84 per year, 95% CI 0.74–0.95) and death from infections (HR 0.86 per year, 95% CI 0.77–0.97). Further, there was a trend towards lower cumulative incidence of death from cardiovascular disease, graft failure and cancer in more recent years, while death from other organ specific and non-organ specific causes did not decrease. All-cause mortality among SOT recipients has decreased over the past decade, mainly due to a decrease in graft rejection- and infection-related deaths. Conversely, deaths from a broad range of other causes have remained unchanged, suggesting that cause of death among SOT recipients is increasingly diverse and warrants a multidisciplinary effort and attention in the future.",
author = "Andreas S{\o}borg and Joanne Reekie and Allan Rasmussen and Cunha-Bang, {Caspar Da} and Finn Gustafsson and Kasper Rossing and Michael Perch and Krohn, {Paul Suno} and S{\o}rensen, {S{\o}ren Schwartz} and Lund, {Thomas Kromann} and S{\o}rensen, {Vibeke R{\o}mming} and Christina Ekenberg and Louise Lundgren and Lodding, {Isabelle Paula} and Moestrup, {Kasper Sommerlund} and Jens Lundgren and Wareham, {Neval Ete}",
note = "Publisher Copyright: Copyright: {\textcopyright} 2022 S{\o}borg et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",
year = "2022",
doi = "10.1371/journal.pone.0263210",
language = "English",
volume = "17",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "7 ",

}

RIS

TY - JOUR

T1 - Trends in underlying causes of death in solid organ transplant recipients between 2010 and 2020

T2 - Using the CLASS method for determining specific causes of death

AU - Søborg, Andreas

AU - Reekie, Joanne

AU - Rasmussen, Allan

AU - Cunha-Bang, Caspar Da

AU - Gustafsson, Finn

AU - Rossing, Kasper

AU - Perch, Michael

AU - Krohn, Paul Suno

AU - Sørensen, Søren Schwartz

AU - Lund, Thomas Kromann

AU - Sørensen, Vibeke Rømming

AU - Ekenberg, Christina

AU - Lundgren, Louise

AU - Lodding, Isabelle Paula

AU - Moestrup, Kasper Sommerlund

AU - Lundgren, Jens

AU - Wareham, Neval Ete

N1 - Publisher Copyright: Copyright: © 2022 Søborg et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2022

Y1 - 2022

N2 - Monitoring specific underlying causes of death in solid organ transplant (SOT) recipients is important in order to identify emerging trends and health challenges. This retrospective cohort study includes all SOT recipients transplanted at Rigshospitalet between January 1st, 2010 and December 31st, 2019. The underlying cause of death was determined using the newly developed Classification of Death Causes after Transplantation (CLASS) method. Cox regression analyses assessed risk factors for all-cause and cause-specific mortality. Of the 1774 SOT recipients included, 299 patients died during a total of 7511 person-years of follow-up (PYFU) with cancer (N = 57, 19%), graft rejection (N = 55, 18%) and infections (N = 52, 17%) being the most frequent causes of death. We observed a lower risk of all-cause death with increasing transplant calendar year (HR 0.91, 95% CI 0.86–0.96 per 1-year increase), alongside death from graft rejection (HR 0.84 per year, 95% CI 0.74–0.95) and death from infections (HR 0.86 per year, 95% CI 0.77–0.97). Further, there was a trend towards lower cumulative incidence of death from cardiovascular disease, graft failure and cancer in more recent years, while death from other organ specific and non-organ specific causes did not decrease. All-cause mortality among SOT recipients has decreased over the past decade, mainly due to a decrease in graft rejection- and infection-related deaths. Conversely, deaths from a broad range of other causes have remained unchanged, suggesting that cause of death among SOT recipients is increasingly diverse and warrants a multidisciplinary effort and attention in the future.

AB - Monitoring specific underlying causes of death in solid organ transplant (SOT) recipients is important in order to identify emerging trends and health challenges. This retrospective cohort study includes all SOT recipients transplanted at Rigshospitalet between January 1st, 2010 and December 31st, 2019. The underlying cause of death was determined using the newly developed Classification of Death Causes after Transplantation (CLASS) method. Cox regression analyses assessed risk factors for all-cause and cause-specific mortality. Of the 1774 SOT recipients included, 299 patients died during a total of 7511 person-years of follow-up (PYFU) with cancer (N = 57, 19%), graft rejection (N = 55, 18%) and infections (N = 52, 17%) being the most frequent causes of death. We observed a lower risk of all-cause death with increasing transplant calendar year (HR 0.91, 95% CI 0.86–0.96 per 1-year increase), alongside death from graft rejection (HR 0.84 per year, 95% CI 0.74–0.95) and death from infections (HR 0.86 per year, 95% CI 0.77–0.97). Further, there was a trend towards lower cumulative incidence of death from cardiovascular disease, graft failure and cancer in more recent years, while death from other organ specific and non-organ specific causes did not decrease. All-cause mortality among SOT recipients has decreased over the past decade, mainly due to a decrease in graft rejection- and infection-related deaths. Conversely, deaths from a broad range of other causes have remained unchanged, suggesting that cause of death among SOT recipients is increasingly diverse and warrants a multidisciplinary effort and attention in the future.

U2 - 10.1371/journal.pone.0263210

DO - 10.1371/journal.pone.0263210

M3 - Journal article

C2 - 35877606

AN - SCOPUS:85135282552

VL - 17

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 7

M1 - e0263210

ER -

ID: 329228658