Trends in Mortality in People With Human Immunodeficiency Virus From 1999 through 2020: A Multicohort Collaboration
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Trends in Mortality in People With Human Immunodeficiency Virus From 1999 through 2020 : A Multicohort Collaboration. / Tusch, Erich; Ryom, Lene; Pelchen-Matthews, Annegret; Mocroft, Amanda; Elbirt, Daniel; Oprea, Cristiana; Günthard, Huldrych F.; Staehelin, Cornelia; Zangerle, Robert; Suarez, Isabelle; Vehreschild, Jörg Janne; Wit, Ferdinand; Menozzi, Marianna; Monforte, Antonella d'Arminio; Spagnuolo, Vincenzo; Pradier, Christian; Carlander, Christina; Suanzes, Paula; Wasmuth, Jan-Christian; Carr, Andrew; Petoumenos, Kathy; Borgans, Frauke; Bonnet, Fabrice; De Wit, Stephane; El-Sadr, Wafaa; Neesgaard, Bastian; Jaschinski, Nadine; Greenberg, Lauren; Hosein, Sean R.; Gallant, Joel; Vannappagari, Vani; Young, Lital; Sabin, Caroline; Lundgren, Jens; Peters, Lars; Reekie, Joanne; D:A:D cohort study ; RESPOND Cohort Collaboration.
In: Clinical Infectious Diseases, 26.04.2024.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Trends in Mortality in People With Human Immunodeficiency Virus From 1999 through 2020
T2 - A Multicohort Collaboration
AU - Tusch, Erich
AU - Ryom, Lene
AU - Pelchen-Matthews, Annegret
AU - Mocroft, Amanda
AU - Elbirt, Daniel
AU - Oprea, Cristiana
AU - Günthard, Huldrych F.
AU - Staehelin, Cornelia
AU - Zangerle, Robert
AU - Suarez, Isabelle
AU - Vehreschild, Jörg Janne
AU - Wit, Ferdinand
AU - Menozzi, Marianna
AU - Monforte, Antonella d'Arminio
AU - Spagnuolo, Vincenzo
AU - Pradier, Christian
AU - Carlander, Christina
AU - Suanzes, Paula
AU - Wasmuth, Jan-Christian
AU - Carr, Andrew
AU - Petoumenos, Kathy
AU - Borgans, Frauke
AU - Bonnet, Fabrice
AU - De Wit, Stephane
AU - El-Sadr, Wafaa
AU - Neesgaard, Bastian
AU - Jaschinski, Nadine
AU - Greenberg, Lauren
AU - Hosein, Sean R.
AU - Gallant, Joel
AU - Vannappagari, Vani
AU - Young, Lital
AU - Sabin, Caroline
AU - Lundgren, Jens
AU - Peters, Lars
AU - Reekie, Joanne
AU - D:A:D cohort study
AU - RESPOND Cohort Collaboration
N1 - © The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.
PY - 2024/4/26
Y1 - 2024/4/26
N2 - BACKGROUND: Mortality among people with HIV declined with the introduction of combination antiretroviral therapy. We investigated trends over time in all-cause and cause-specific mortality in people with HIV from 1999-2020.METHODS: Data were collected from the D:A:D cohort from 1999 through January 2015 and RESPOND from October 2017 through 2020. Age-standardized all-cause and cause-specific mortality rates, classified using Coding Causes of Death in HIV (CoDe), were calculated. Poisson regression models were used to assess mortality trends over time.RESULTS: Among 55716 participants followed for a median of 6 years (IQR 3-11), 5263 participants died (crude mortality rate [MR] 13.7/1000 PYFU; 95%CI 13.4-14.1). Changing patterns of mortality were observed with AIDS as the most common cause of death between 1999- 2009 (n = 952, MR 4.2/1000 PYFU; 95%CI 4.0-4.5) and non-AIDS defining malignancy (NADM) from 2010 -2020 (n = 444, MR 2.8/1000 PYFU; 95%CI 2.5-3.1). In multivariable analysis, all-cause mortality declined over time (adjusted mortality rate ratio [aMRR] 0.97 per year; 95%CI 0.96, 0.98), mostly from 1999 through 2010 (aMRR 0.96 per year; 95%CI 0.95-0.97), and with no decline shown from 2011 through 2020 (aMRR 1·00 per year; 95%CI 0·96-1·05). Mortality due all known causes except NADM also declined over the entire follow-up period.CONCLUSION: Mortality among people with HIV in the D:A:D and/or RESPOND cohorts decreased between 1999 and 2009 and was stable over the period from 2010 through 2020. The decline in mortality rates was not fully explained by improvements in immunologic-virologic status or other risk factors.
AB - BACKGROUND: Mortality among people with HIV declined with the introduction of combination antiretroviral therapy. We investigated trends over time in all-cause and cause-specific mortality in people with HIV from 1999-2020.METHODS: Data were collected from the D:A:D cohort from 1999 through January 2015 and RESPOND from October 2017 through 2020. Age-standardized all-cause and cause-specific mortality rates, classified using Coding Causes of Death in HIV (CoDe), were calculated. Poisson regression models were used to assess mortality trends over time.RESULTS: Among 55716 participants followed for a median of 6 years (IQR 3-11), 5263 participants died (crude mortality rate [MR] 13.7/1000 PYFU; 95%CI 13.4-14.1). Changing patterns of mortality were observed with AIDS as the most common cause of death between 1999- 2009 (n = 952, MR 4.2/1000 PYFU; 95%CI 4.0-4.5) and non-AIDS defining malignancy (NADM) from 2010 -2020 (n = 444, MR 2.8/1000 PYFU; 95%CI 2.5-3.1). In multivariable analysis, all-cause mortality declined over time (adjusted mortality rate ratio [aMRR] 0.97 per year; 95%CI 0.96, 0.98), mostly from 1999 through 2010 (aMRR 0.96 per year; 95%CI 0.95-0.97), and with no decline shown from 2011 through 2020 (aMRR 1·00 per year; 95%CI 0·96-1·05). Mortality due all known causes except NADM also declined over the entire follow-up period.CONCLUSION: Mortality among people with HIV in the D:A:D and/or RESPOND cohorts decreased between 1999 and 2009 and was stable over the period from 2010 through 2020. The decline in mortality rates was not fully explained by improvements in immunologic-virologic status or other risk factors.
U2 - 10.1093/cid/ciae228
DO - 10.1093/cid/ciae228
M3 - Journal article
C2 - 38663013
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
SN - 1058-4838
ER -
ID: 395580851