Transoral robotic surgery for the management of head and neck squamous cell carcinoma of unknown primary
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Transoral robotic surgery for the management of head and neck squamous cell carcinoma of unknown primary. / Channir, Hani Ibrahim; Rubek, Niclas; Nielsen, Hans Ulrik; Kiss, Katalin; Charabi, Birgitte W; Lajer, Christel B; von Buchwald, Christian.
In: Acta Oto-Laryngologica, Vol. 135, No. 10, 2015, p. 1051-7.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Transoral robotic surgery for the management of head and neck squamous cell carcinoma of unknown primary
AU - Channir, Hani Ibrahim
AU - Rubek, Niclas
AU - Nielsen, Hans Ulrik
AU - Kiss, Katalin
AU - Charabi, Birgitte W
AU - Lajer, Christel B
AU - von Buchwald, Christian
PY - 2015
Y1 - 2015
N2 - CONCLUSION: The addition of transoral robotic surgery (TORS) in the diagnostic management of patients classified with head and neck squamous cell carcinoma of unknown primary (SCCUP) is promising and appears to improve detection rates of the primary tumour. The approach presented in this first Scandinavian study could potentially minimize the radiation field to the pharyngeal axis in patients with identified primary tumours.OBJECTIVES: The aim of the study was to investigate whether bilateral lingual tonsillectomy performed with TORS is feasible, and whether it could improve the detection rates of primary tumours in patients diagnosed and classified as having SCCUP.METHODS: The study was retrospective and included 13 patients with SCCUP who were referred to TORS between October 2013 and January 2015. All 13 patients had previously undergone a full investigation programme following the national guidelines including whole-body PET/CT, examination in general anaesthesia, including random biopsies of the base of the tongue and bilateral palatine tonsillectomy without identification of the primary tumour.RESULTS: The primary tumour was identified by TORS in seven of the 13 patients (54%) at the lingual tonsils. Human papillomavirus DNA and p16 were positive in all identified primary tumour specimens and in the corresponding lymph node metastases.
AB - CONCLUSION: The addition of transoral robotic surgery (TORS) in the diagnostic management of patients classified with head and neck squamous cell carcinoma of unknown primary (SCCUP) is promising and appears to improve detection rates of the primary tumour. The approach presented in this first Scandinavian study could potentially minimize the radiation field to the pharyngeal axis in patients with identified primary tumours.OBJECTIVES: The aim of the study was to investigate whether bilateral lingual tonsillectomy performed with TORS is feasible, and whether it could improve the detection rates of primary tumours in patients diagnosed and classified as having SCCUP.METHODS: The study was retrospective and included 13 patients with SCCUP who were referred to TORS between October 2013 and January 2015. All 13 patients had previously undergone a full investigation programme following the national guidelines including whole-body PET/CT, examination in general anaesthesia, including random biopsies of the base of the tongue and bilateral palatine tonsillectomy without identification of the primary tumour.RESULTS: The primary tumour was identified by TORS in seven of the 13 patients (54%) at the lingual tonsils. Human papillomavirus DNA and p16 were positive in all identified primary tumour specimens and in the corresponding lymph node metastases.
KW - Aged
KW - Carcinoma, Squamous Cell
KW - Female
KW - Head and Neck Neoplasms
KW - Humans
KW - Male
KW - Middle Aged
KW - Mouth
KW - Natural Orifice Endoscopic Surgery
KW - Neoplasm Staging
KW - Neoplasms, Unknown Primary
KW - Positron-Emission Tomography
KW - Retrospective Studies
KW - Robotics
KW - Tomography, X-Ray Computed
KW - Treatment Outcome
U2 - 10.3109/00016489.2015.1052983
DO - 10.3109/00016489.2015.1052983
M3 - Journal article
C2 - 26073750
VL - 135
SP - 1051
EP - 1057
JO - Acta Oto-Laryngologica
JF - Acta Oto-Laryngologica
SN - 0001-6489
IS - 10
ER -
ID: 162901074