Transmembrane signalling via HLA-DR molecules on T cells from a Sezary T-cell leukaemia line
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Transmembrane signalling via HLA-DR molecules on T cells from a Sezary T-cell leukaemia line. / Geisler, C; Kuhlmann, J; Møller, T; Plesner, T; Rubin, B.
In: Scandinavian Journal of Immunology, Vol. 32, No. 6, 1990, p. 731-5.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Transmembrane signalling via HLA-DR molecules on T cells from a Sezary T-cell leukaemia line
AU - Geisler, C
AU - Kuhlmann, J
AU - Møller, T
AU - Plesner, T
AU - Rubin, B
N1 - Keywords: Antibodies, Monoclonal; Antigens, CD; Antigens, CD3; Antigens, Differentiation, T-Lymphocyte; Cells, Cultured; Cross-Linking Reagents; Gene Expression Regulation, Neoplastic; HLA-DR Antigens; Humans; Interleukin-2; Receptors, Antigen, T-Cell; Sezary Syndrome; Signal Transduction; T-Lymphocytes; Tumor Cells, Cultured
PY - 1990
Y1 - 1990
N2 - The human Sezary T-cell leukaemia line, HUT.78, represents a population of activated T cells, i.e. they are HLA-DR+ and IL-2R+. We have analysed the capacity of HUT.78 cells (1) to stimulate HLA-DR-specific T-cell lines or clones and (2) to be induced to synthesize IL-2 by anti-HLA-DR monoclonal antibodies. The results of our experiments show that HLA-DR molecules on HUT.78 cells can stimulate at least one HLA-DR-specific T-cell clone and can act as transmembrane signal transmitters.
AB - The human Sezary T-cell leukaemia line, HUT.78, represents a population of activated T cells, i.e. they are HLA-DR+ and IL-2R+. We have analysed the capacity of HUT.78 cells (1) to stimulate HLA-DR-specific T-cell lines or clones and (2) to be induced to synthesize IL-2 by anti-HLA-DR monoclonal antibodies. The results of our experiments show that HLA-DR molecules on HUT.78 cells can stimulate at least one HLA-DR-specific T-cell clone and can act as transmembrane signal transmitters.
M3 - Journal article
C2 - 2148646
VL - 32
SP - 731
EP - 735
JO - Scandinavian Journal of Immunology, Supplement
JF - Scandinavian Journal of Immunology, Supplement
SN - 0301-6323
IS - 6
ER -
ID: 8546274