Translational control and differential RNA decay are key elements regulating postsegregational expression of the killer protein encoded by the parB locus of plasmid R1.

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Translational control and differential RNA decay are key elements regulating postsegregational expression of the killer protein encoded by the parB locus of plasmid R1. / Gerdes, K; Helin, K; Christensen, O W; Løbner-Olesen, A.

In: Journal of Molecular Biology, Vol. 203, No. 1, 1988, p. 119-29.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Gerdes, K, Helin, K, Christensen, OW & Løbner-Olesen, A 1988, 'Translational control and differential RNA decay are key elements regulating postsegregational expression of the killer protein encoded by the parB locus of plasmid R1.', Journal of Molecular Biology, vol. 203, no. 1, pp. 119-29.

APA

Gerdes, K., Helin, K., Christensen, O. W., & Løbner-Olesen, A. (1988). Translational control and differential RNA decay are key elements regulating postsegregational expression of the killer protein encoded by the parB locus of plasmid R1. Journal of Molecular Biology, 203(1), 119-29.

Vancouver

Gerdes K, Helin K, Christensen OW, Løbner-Olesen A. Translational control and differential RNA decay are key elements regulating postsegregational expression of the killer protein encoded by the parB locus of plasmid R1. Journal of Molecular Biology. 1988;203(1):119-29.

Author

Gerdes, K ; Helin, K ; Christensen, O W ; Løbner-Olesen, A. / Translational control and differential RNA decay are key elements regulating postsegregational expression of the killer protein encoded by the parB locus of plasmid R1. In: Journal of Molecular Biology. 1988 ; Vol. 203, No. 1. pp. 119-29.

Bibtex

@article{1ea56a4053eb11dd8d9f000ea68e967b,
title = "Translational control and differential RNA decay are key elements regulating postsegregational expression of the killer protein encoded by the parB locus of plasmid R1.",
abstract = "The parB locus of plasmid R1, which mediates plasmid stability via postsegregational killing of plasmid-free cells, encodes two genes, hok and sok. The hok gene product is a potent cell-killing protein. The hok gene is regulated at the translational level by the sok gene-encoded repressor, a small anti-sense RNA complementary to the hok mRNA. The hok mRNA is extraordinarily stable, while the sok RNA decays rapidly. The mechanism of postsegregational killing is explained by the following model; the sok RNA molecule rapidly disappears in cells that have lost a parB-carrying plasmid, leading to translation of the stable hok mRNA. Consequently, the Hok protein is synthesized and killing of the plasmid-free cell follows.",
author = "K Gerdes and K Helin and Christensen, {O W} and A L{\o}bner-Olesen",
note = "Keywords: Base Sequence; Chromosome Mapping; Escherichia coli; Gene Expression Regulation; Genes, Bacterial; Molecular Sequence Data; Promoter Regions (Genetics); Protein Biosynthesis; R Factors; RNA, Bacterial; RNA, Messenger; Rifampin; Suppression, Genetic",
year = "1988",
language = "English",
volume = "203",
pages = "119--29",
journal = "Journal of Molecular Biology",
issn = "0022-2836",
publisher = "Academic Press",
number = "1",

}

RIS

TY - JOUR

T1 - Translational control and differential RNA decay are key elements regulating postsegregational expression of the killer protein encoded by the parB locus of plasmid R1.

AU - Gerdes, K

AU - Helin, K

AU - Christensen, O W

AU - Løbner-Olesen, A

N1 - Keywords: Base Sequence; Chromosome Mapping; Escherichia coli; Gene Expression Regulation; Genes, Bacterial; Molecular Sequence Data; Promoter Regions (Genetics); Protein Biosynthesis; R Factors; RNA, Bacterial; RNA, Messenger; Rifampin; Suppression, Genetic

PY - 1988

Y1 - 1988

N2 - The parB locus of plasmid R1, which mediates plasmid stability via postsegregational killing of plasmid-free cells, encodes two genes, hok and sok. The hok gene product is a potent cell-killing protein. The hok gene is regulated at the translational level by the sok gene-encoded repressor, a small anti-sense RNA complementary to the hok mRNA. The hok mRNA is extraordinarily stable, while the sok RNA decays rapidly. The mechanism of postsegregational killing is explained by the following model; the sok RNA molecule rapidly disappears in cells that have lost a parB-carrying plasmid, leading to translation of the stable hok mRNA. Consequently, the Hok protein is synthesized and killing of the plasmid-free cell follows.

AB - The parB locus of plasmid R1, which mediates plasmid stability via postsegregational killing of plasmid-free cells, encodes two genes, hok and sok. The hok gene product is a potent cell-killing protein. The hok gene is regulated at the translational level by the sok gene-encoded repressor, a small anti-sense RNA complementary to the hok mRNA. The hok mRNA is extraordinarily stable, while the sok RNA decays rapidly. The mechanism of postsegregational killing is explained by the following model; the sok RNA molecule rapidly disappears in cells that have lost a parB-carrying plasmid, leading to translation of the stable hok mRNA. Consequently, the Hok protein is synthesized and killing of the plasmid-free cell follows.

M3 - Journal article

C2 - 2460630

VL - 203

SP - 119

EP - 129

JO - Journal of Molecular Biology

JF - Journal of Molecular Biology

SN - 0022-2836

IS - 1

ER -

ID: 5053487