Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis
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Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis. / Sato, Shogo; Basse, Astrid Linde; Schönke, Milena; Chen, Siwei; Samad, Muntaha; Altıntaş, Ali; Laker, Rhianna C; Dalbram, Emilie; Barrès, Romain; Baldi, Pierre; Treebak, Jonas T.; Zierath, Juleen R; Sassone-Corsi, Paolo.
In: Cell Metabolism, Vol. 30, No. 1, 2019, p. 92-110.e4.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis
AU - Sato, Shogo
AU - Basse, Astrid Linde
AU - Schönke, Milena
AU - Chen, Siwei
AU - Samad, Muntaha
AU - Altıntaş, Ali
AU - Laker, Rhianna C
AU - Dalbram, Emilie
AU - Barrès, Romain
AU - Baldi, Pierre
AU - Treebak, Jonas T.
AU - Zierath, Juleen R
AU - Sassone-Corsi, Paolo
PY - 2019
Y1 - 2019
N2 - While the timing of food intake is important, it is unclear whether the effects of exercise on energy metabolism are restricted to unique time windows. As circadian regulation is key to controlling metabolism, understanding the impact of exercise performed at different times of the day is relevant for physiology and homeostasis. Using high-throughput transcriptomic and metabolomic approaches, we identify distinct responses of metabolic oscillations that characterize exercise in either the early rest phase or the early active phase in mice. Notably, glycolytic activation is specific to exercise at the active phase. At the molecular level, HIF1α, a central regulator of glycolysis during hypoxia, is selectively activated in a time-dependent manner upon exercise, resulting in carbohydrate exhaustion, usage of alternative energy sources, and adaptation of systemic energy expenditure. Our findings demonstrate that the time of day is a critical factor to amplify the beneficial impact of exercise on both metabolic pathways within skeletal muscle and systemic energy homeostasis.
AB - While the timing of food intake is important, it is unclear whether the effects of exercise on energy metabolism are restricted to unique time windows. As circadian regulation is key to controlling metabolism, understanding the impact of exercise performed at different times of the day is relevant for physiology and homeostasis. Using high-throughput transcriptomic and metabolomic approaches, we identify distinct responses of metabolic oscillations that characterize exercise in either the early rest phase or the early active phase in mice. Notably, glycolytic activation is specific to exercise at the active phase. At the molecular level, HIF1α, a central regulator of glycolysis during hypoxia, is selectively activated in a time-dependent manner upon exercise, resulting in carbohydrate exhaustion, usage of alternative energy sources, and adaptation of systemic energy expenditure. Our findings demonstrate that the time of day is a critical factor to amplify the beneficial impact of exercise on both metabolic pathways within skeletal muscle and systemic energy homeostasis.
U2 - 10.1016/j.cmet.2019.03.013
DO - 10.1016/j.cmet.2019.03.013
M3 - Journal article
C2 - 31006592
VL - 30
SP - 92-110.e4
JO - Cell Metabolism
JF - Cell Metabolism
SN - 1550-4131
IS - 1
ER -
ID: 216980626