Theory of thermal anomalies in the specific heat of lipid bilayers containing cholesterol
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Theory of thermal anomalies in the specific heat of lipid bilayers containing cholesterol. / Ipsen, J. H.; Mouritsen, O. G.; Zuckermann, M. J.
In: Biophysical Journal, Vol. 56, No. 4, 1989, p. 661-667.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Theory of thermal anomalies in the specific heat of lipid bilayers containing cholesterol
AU - Ipsen, J. H.
AU - Mouritsen, O. G.
AU - Zuckermann, M. J.
PY - 1989
Y1 - 1989
N2 - A theoretical explanation of the experimentally observed characteristic thermal anomalies in the specific heat of lipid bilayers containing cholesterol is provided in terms of the phase equilibria in the phosphatidylcholine-cholesterol system. The phase equilibria are calculated via a microscopic interaction model that takes proper account of both the conformational and the crystalline degrees of freedom of the lipid acyl chains. It is shown that the characteristic double-peaked specific heat, with a narrow and a broad component, is a natural consequence of the topology of the phase diagram. Some results for the enthalpy of the mixed system are also reported. It is suggested that there is no need for invoking special mechanisms such as lipid-cholesterol complexing or formation of special interfacial regions in the bilayer in order to explain the specific-heat anomalies.
AB - A theoretical explanation of the experimentally observed characteristic thermal anomalies in the specific heat of lipid bilayers containing cholesterol is provided in terms of the phase equilibria in the phosphatidylcholine-cholesterol system. The phase equilibria are calculated via a microscopic interaction model that takes proper account of both the conformational and the crystalline degrees of freedom of the lipid acyl chains. It is shown that the characteristic double-peaked specific heat, with a narrow and a broad component, is a natural consequence of the topology of the phase diagram. Some results for the enthalpy of the mixed system are also reported. It is suggested that there is no need for invoking special mechanisms such as lipid-cholesterol complexing or formation of special interfacial regions in the bilayer in order to explain the specific-heat anomalies.
U2 - 10.1016/S0006-3495(89)82713-4
DO - 10.1016/S0006-3495(89)82713-4
M3 - Journal article
C2 - 2819232
AN - SCOPUS:0024740905
VL - 56
SP - 661
EP - 667
JO - Biophysical Society. Annual Meeting. Abstracts
JF - Biophysical Society. Annual Meeting. Abstracts
SN - 0523-6800
IS - 4
ER -
ID: 238387470