Theory of protein-induced lateral phase separation in lipid membranes
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Theory of protein-induced lateral phase separation in lipid membranes. / Sperotto, Maria M.; Ipsen, John Hjort; Mouritsen, Ole G.
In: Cell Biochemistry and Biophysics, Vol. 14, No. 1, 1989, p. 79-95.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Theory of protein-induced lateral phase separation in lipid membranes
AU - Sperotto, Maria M.
AU - Ipsen, John Hjort
AU - Mouritsen, Ole G.
PY - 1989
Y1 - 1989
N2 - An account is given of the current status of theoretical modeling of the phase equilibria in lipid membranes with intrinsic proteins. Special attention is paid to the description of lateral phase separation, which is important for membrane function since it may lead to biologically differentiated regions. We discuss in particular the mattressmodel approach by Mouritsen and Bloom (37), who take matching between protein and lipid hydrophobic thicknesses as a determining factor for the phase behavior. The model has been developed in the framework of phenomenological thermodynamics solution theory. The predictions of the theory are compared to a variety of experimental measurements, including those of membrane recombinants of the protein content of the reaction center and antenna protein of the bacterial photosynthetic apparatus as well as the erythrocyte band 3 protein. The physical effects of lipid-protein interactions are contrasted to those of lipid-cholesterol interactions. The concept of hydrophobic matching is then used as a basis for discussing a possible relationship between membrane thickness and physiological function.
AB - An account is given of the current status of theoretical modeling of the phase equilibria in lipid membranes with intrinsic proteins. Special attention is paid to the description of lateral phase separation, which is important for membrane function since it may lead to biologically differentiated regions. We discuss in particular the mattressmodel approach by Mouritsen and Bloom (37), who take matching between protein and lipid hydrophobic thicknesses as a determining factor for the phase behavior. The model has been developed in the framework of phenomenological thermodynamics solution theory. The predictions of the theory are compared to a variety of experimental measurements, including those of membrane recombinants of the protein content of the reaction center and antenna protein of the bacterial photosynthetic apparatus as well as the erythrocyte band 3 protein. The physical effects of lipid-protein interactions are contrasted to those of lipid-cholesterol interactions. The concept of hydrophobic matching is then used as a basis for discussing a possible relationship between membrane thickness and physiological function.
KW - cholesterol
KW - hydrophobic thickness
KW - lipid membranes
KW - Lipid-protein interactions
KW - phase separation
KW - phase transition
KW - solution theory
KW - statistical mechanics
KW - thermodynamics
U2 - 10.1007/BF02797393
DO - 10.1007/BF02797393
M3 - Journal article
C2 - 2465088
AN - SCOPUS:0024400738
VL - 14
SP - 79
EP - 95
JO - Cell Biochemistry and Biophysics
JF - Cell Biochemistry and Biophysics
SN - 1085-9195
IS - 1
ER -
ID: 238387687