The versatility of the mitochondrial presequence processing machinery: cleavage, quality control and turnover

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The versatility of the mitochondrial presequence processing machinery : cleavage, quality control and turnover. / Poveda-Huertes, Daniel; Mulica, Patrycja; Vögtle, F Nora.

In: Cell and Tissue Research, Vol. 367, No. 1, 01.2017, p. 73-81.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Poveda-Huertes, D, Mulica, P & Vögtle, FN 2017, 'The versatility of the mitochondrial presequence processing machinery: cleavage, quality control and turnover', Cell and Tissue Research, vol. 367, no. 1, pp. 73-81. https://doi.org/10.1007/s00441-016-2492-9

APA

Poveda-Huertes, D., Mulica, P., & Vögtle, F. N. (2017). The versatility of the mitochondrial presequence processing machinery: cleavage, quality control and turnover. Cell and Tissue Research, 367(1), 73-81. https://doi.org/10.1007/s00441-016-2492-9

Vancouver

Poveda-Huertes D, Mulica P, Vögtle FN. The versatility of the mitochondrial presequence processing machinery: cleavage, quality control and turnover. Cell and Tissue Research. 2017 Jan;367(1):73-81. https://doi.org/10.1007/s00441-016-2492-9

Author

Poveda-Huertes, Daniel ; Mulica, Patrycja ; Vögtle, F Nora. / The versatility of the mitochondrial presequence processing machinery : cleavage, quality control and turnover. In: Cell and Tissue Research. 2017 ; Vol. 367, No. 1. pp. 73-81.

Bibtex

@article{7d2f59ac5d234a458ee929a498fd4453,
title = "The versatility of the mitochondrial presequence processing machinery: cleavage, quality control and turnover",
abstract = "Mitochondria play a key role in several metabolic and cell biological pathways and have attracted increasing attention due to their implication in life-span, ageing and human diseases. Mitochondrial proteases have a special role in these multiple biological functions, as they are involved in the regulation of various processes, e.g., mitochondrial protein biogenesis and quality control, mitochondrial dynamics, mitophagy and programmed cell death. The mitochondrial presequence processing machinery serves the particular purpose of maturing the majority of incoming precursor proteins by presequence cleavage, to ensure a stable mature protein by trimming of intermediate N-termini and to remove free toxic targeting peptides.",
keywords = "Amino Acid Sequence, Animals, Disease, Humans, Mitochondria/metabolism, Mitochondrial Proteins/chemistry, Peptide Hydrolases/metabolism, Protein Processing, Post-Translational",
author = "Daniel Poveda-Huertes and Patrycja Mulica and V{\"o}gtle, {F Nora}",
year = "2017",
month = jan,
doi = "10.1007/s00441-016-2492-9",
language = "English",
volume = "367",
pages = "73--81",
journal = "Cell and Tissue Research",
issn = "0302-766X",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - The versatility of the mitochondrial presequence processing machinery

T2 - cleavage, quality control and turnover

AU - Poveda-Huertes, Daniel

AU - Mulica, Patrycja

AU - Vögtle, F Nora

PY - 2017/1

Y1 - 2017/1

N2 - Mitochondria play a key role in several metabolic and cell biological pathways and have attracted increasing attention due to their implication in life-span, ageing and human diseases. Mitochondrial proteases have a special role in these multiple biological functions, as they are involved in the regulation of various processes, e.g., mitochondrial protein biogenesis and quality control, mitochondrial dynamics, mitophagy and programmed cell death. The mitochondrial presequence processing machinery serves the particular purpose of maturing the majority of incoming precursor proteins by presequence cleavage, to ensure a stable mature protein by trimming of intermediate N-termini and to remove free toxic targeting peptides.

AB - Mitochondria play a key role in several metabolic and cell biological pathways and have attracted increasing attention due to their implication in life-span, ageing and human diseases. Mitochondrial proteases have a special role in these multiple biological functions, as they are involved in the regulation of various processes, e.g., mitochondrial protein biogenesis and quality control, mitochondrial dynamics, mitophagy and programmed cell death. The mitochondrial presequence processing machinery serves the particular purpose of maturing the majority of incoming precursor proteins by presequence cleavage, to ensure a stable mature protein by trimming of intermediate N-termini and to remove free toxic targeting peptides.

KW - Amino Acid Sequence

KW - Animals

KW - Disease

KW - Humans

KW - Mitochondria/metabolism

KW - Mitochondrial Proteins/chemistry

KW - Peptide Hydrolases/metabolism

KW - Protein Processing, Post-Translational

U2 - 10.1007/s00441-016-2492-9

DO - 10.1007/s00441-016-2492-9

M3 - Review

C2 - 27595151

VL - 367

SP - 73

EP - 81

JO - Cell and Tissue Research

JF - Cell and Tissue Research

SN - 0302-766X

IS - 1

ER -

ID: 391635993