The role of leptin in fetal growth during pre-eclampsia
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The role of leptin in fetal growth during pre-eclampsia. / de Knegt, Victoria E.; Hedley, Paula L.; Kanters, Jørgen K.; Thagaard, Ida N.; Krebs, Lone; Christiansen, Michael; Lausten-Thomsen, Ulrik.
In: International Journal of Molecular Sciences, Vol. 22, No. 9, 4569, 01.05.2021.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - The role of leptin in fetal growth during pre-eclampsia
AU - de Knegt, Victoria E.
AU - Hedley, Paula L.
AU - Kanters, Jørgen K.
AU - Thagaard, Ida N.
AU - Krebs, Lone
AU - Christiansen, Michael
AU - Lausten-Thomsen, Ulrik
PY - 2021/5/1
Y1 - 2021/5/1
N2 - Leptin is secreted by the placenta and has a multi-facetted role in the regulation of functions related to pregnancy. Metabolic disorders and insufficient homeostatic compensatory mechanisms involving leptin during pregnancy play a decisive role in the development of pre-eclampsia (PE) and give rise to compromised intrauterine growth conditions and aberrant birth weight of offspring. This review was compiled to elucidate the metabolic background of PE and its relationship with adverse intrauterine growth conditions through the examination of leptin as well as to describe possible mechanisms linking leptin to fetal growth restriction. This review illustrates that leptin in PE is dysregulated in maternal, fetal, and placental compartments. There is no single set of unifying mechanisms within the spectrum of PE, and regulatory mechanisms involving leptin are specific to each situation. We conclude that dysregulated leptin is involved in fetal growth at many levels through complex interactions with parallel pregnancy systems and probably throughout the entirety of pregnancy.
AB - Leptin is secreted by the placenta and has a multi-facetted role in the regulation of functions related to pregnancy. Metabolic disorders and insufficient homeostatic compensatory mechanisms involving leptin during pregnancy play a decisive role in the development of pre-eclampsia (PE) and give rise to compromised intrauterine growth conditions and aberrant birth weight of offspring. This review was compiled to elucidate the metabolic background of PE and its relationship with adverse intrauterine growth conditions through the examination of leptin as well as to describe possible mechanisms linking leptin to fetal growth restriction. This review illustrates that leptin in PE is dysregulated in maternal, fetal, and placental compartments. There is no single set of unifying mechanisms within the spectrum of PE, and regulatory mechanisms involving leptin are specific to each situation. We conclude that dysregulated leptin is involved in fetal growth at many levels through complex interactions with parallel pregnancy systems and probably throughout the entirety of pregnancy.
KW - Anthropometry
KW - Birth weight
KW - Fetal development
KW - Fetal growth restriction
KW - Infant growth
KW - Leptin
KW - Pre-eclampsia
KW - Prenatal growth
U2 - 10.3390/ijms22094569
DO - 10.3390/ijms22094569
M3 - Review
C2 - 33925454
AN - SCOPUS:85104791187
VL - 22
JO - International Journal of Molecular Sciences (CD-ROM)
JF - International Journal of Molecular Sciences (CD-ROM)
SN - 1424-6783
IS - 9
M1 - 4569
ER -
ID: 261331262