The role of interleukin-1β in the immune response to contact allergens
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The role of interleukin-1β in the immune response to contact allergens. / Yeung, Kelvin; Mraz, Veronika; Geisler, Carsten; Skov, Lone; Bonefeld, Charlotte M.
In: Contact Dermatitis, Vol. 85, No. 4, 2021, p. 387-397.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - The role of interleukin-1β in the immune response to contact allergens
AU - Yeung, Kelvin
AU - Mraz, Veronika
AU - Geisler, Carsten
AU - Skov, Lone
AU - Bonefeld, Charlotte M.
N1 - Publisher Copyright: © 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
PY - 2021
Y1 - 2021
N2 - Interleukin-1β (IL-1β) is an important pro-inflammatory cytokine that has an effect on almost every cell lineage in the body. By blocking IL-1β and investigating the IL-1β signaling pathway, several studies have demonstrated a central role of IL-1β in the response to contact allergens. This review summarizes the current literature regarding the basic immunological mechanisms mediated by IL-1β in the different phases of allergic contact dermatitis (ACD) and highlights potential IL-1β-targeted treatment options, which in the future may be relevant in the treatment of patients with ACD. This review is based primarily on studies using various mouse models and human in vitro studies, since clinical studies on the effect of IL-1β in ACD are lacking.
AB - Interleukin-1β (IL-1β) is an important pro-inflammatory cytokine that has an effect on almost every cell lineage in the body. By blocking IL-1β and investigating the IL-1β signaling pathway, several studies have demonstrated a central role of IL-1β in the response to contact allergens. This review summarizes the current literature regarding the basic immunological mechanisms mediated by IL-1β in the different phases of allergic contact dermatitis (ACD) and highlights potential IL-1β-targeted treatment options, which in the future may be relevant in the treatment of patients with ACD. This review is based primarily on studies using various mouse models and human in vitro studies, since clinical studies on the effect of IL-1β in ACD are lacking.
KW - allergic contact dermatitis
KW - immunology
KW - interleukin-1β
KW - T cells
U2 - 10.1111/cod.13955
DO - 10.1111/cod.13955
M3 - Review
C2 - 34324721
AN - SCOPUS:85112049290
VL - 85
SP - 387
EP - 397
JO - Contact Dermatitis
JF - Contact Dermatitis
SN - 0105-1873
IS - 4
ER -
ID: 276272022