The risk of asthma is increased among women with polycystic ovary syndrome: a twin study
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The risk of asthma is increased among women with polycystic ovary syndrome : a twin study. / Zierau, Louise; Meteran, Howraman; Backer, Vibeke; Lindenberg, Svend; Skytthe, Axel; Thomsen, Simon Francis.
In: ERJ Open Research, Vol. 5, No. 3, 00018-2018, 09.2019.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The risk of asthma is increased among women with polycystic ovary syndrome
T2 - a twin study
AU - Zierau, Louise
AU - Meteran, Howraman
AU - Backer, Vibeke
AU - Lindenberg, Svend
AU - Skytthe, Axel
AU - Thomsen, Simon Francis
PY - 2019/9
Y1 - 2019/9
N2 - Background: Recent registry studies have demonstrated a higher prevalence of asthma among women with polycystic ovary syndrome (PCOS). We aimed to assess the association and heritability of PCOS and asthma in a Danish twin cohort.Methods: Data for 32 382 female twins from the Danish Twin Registry were included. Twins with PCOS were identified by searching the Danish National Patient Registry for International Classification of Diseases-10 code E28.2. Asthma was diagnosed by questionnaires.Results: 103 (0.3%) women had a PCOS diagnosis. The risk of asthma was increased among women with PCOS compared with women without (18% versus 9%, respectively; OR 2.11 (95% CI 1.13-3.96); p=0.02). After adjustment for age, body mass index, alcohol consumption and smoking status, the risk of asthma was still increased, but was no longer statistically significant (OR 1.54 (95% CI 0.75-3.17); p=0.24). Variance components analysis showed that shared environmental factors explained 49% (95% CI 24-68%) and unique environmental factors explained 51% (95% CI 32-76%) of the susceptibility to PCOS. For asthma, 44% (95% CI 28-61%) of the variance was explained by genetic factors, whereas 25% (95% CI 11-38%) was ascribable to shared environmental factors and 31% (95% CI 26-36%) to unique environmental factors.Conclusion: The risk of asthma is twice as high among female twins with PCOS. The individual susceptibility to PCOS is mainly due to environmental factors and not genetics.
AB - Background: Recent registry studies have demonstrated a higher prevalence of asthma among women with polycystic ovary syndrome (PCOS). We aimed to assess the association and heritability of PCOS and asthma in a Danish twin cohort.Methods: Data for 32 382 female twins from the Danish Twin Registry were included. Twins with PCOS were identified by searching the Danish National Patient Registry for International Classification of Diseases-10 code E28.2. Asthma was diagnosed by questionnaires.Results: 103 (0.3%) women had a PCOS diagnosis. The risk of asthma was increased among women with PCOS compared with women without (18% versus 9%, respectively; OR 2.11 (95% CI 1.13-3.96); p=0.02). After adjustment for age, body mass index, alcohol consumption and smoking status, the risk of asthma was still increased, but was no longer statistically significant (OR 1.54 (95% CI 0.75-3.17); p=0.24). Variance components analysis showed that shared environmental factors explained 49% (95% CI 24-68%) and unique environmental factors explained 51% (95% CI 32-76%) of the susceptibility to PCOS. For asthma, 44% (95% CI 28-61%) of the variance was explained by genetic factors, whereas 25% (95% CI 11-38%) was ascribable to shared environmental factors and 31% (95% CI 26-36%) to unique environmental factors.Conclusion: The risk of asthma is twice as high among female twins with PCOS. The individual susceptibility to PCOS is mainly due to environmental factors and not genetics.
U2 - 10.1183/23120541.00018-2018
DO - 10.1183/23120541.00018-2018
M3 - Journal article
C2 - 31544109
VL - 5
JO - ERJ Open Research
JF - ERJ Open Research
SN - 2312-0541
IS - 3
M1 - 00018-2018
ER -
ID: 241159930