The Met1-Linked Ubiquitin Machinery: Emerging Themes of (De)regulation
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The Met1-Linked Ubiquitin Machinery : Emerging Themes of (De)regulation. / Hrdinka, Matous; Gyrd-Hansen, Mads.
In: Molecular Cell, Vol. 68, No. 2, 19.10.2017, p. 265-280.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - The Met1-Linked Ubiquitin Machinery
T2 - Emerging Themes of (De)regulation
AU - Hrdinka, Matous
AU - Gyrd-Hansen, Mads
N1 - Copyright © 2017 Elsevier Inc. All rights reserved.
PY - 2017/10/19
Y1 - 2017/10/19
N2 - The linear ubiquitin chain assembly complex, LUBAC, is the only known mammalian ubiquitin ligase that makes methionine 1 (Met1)-linked polyubiquitin (also referred to as linear ubiquitin). A decade after LUBAC was discovered as a cellular activity of unknown function, there are now many lines of evidence connecting Met1-linked polyubiquitin to NF-κB signaling, cell death, inflammation, immunity, and cancer. We now know that Met1-linked polyubiquitin has potent signaling functions and that its deregulation is connected to disease. Indeed, mutations and deficiencies in several factors involved in conjugation and deconjugation of Met1-linked polyubiquitin have been implicated in immune-related disorders. Here, we discuss current knowledge and recent insights into the role and regulation of Met1-linked polyubiquitin, with an emphasis on the mechanisms controlling the function of LUBAC.
AB - The linear ubiquitin chain assembly complex, LUBAC, is the only known mammalian ubiquitin ligase that makes methionine 1 (Met1)-linked polyubiquitin (also referred to as linear ubiquitin). A decade after LUBAC was discovered as a cellular activity of unknown function, there are now many lines of evidence connecting Met1-linked polyubiquitin to NF-κB signaling, cell death, inflammation, immunity, and cancer. We now know that Met1-linked polyubiquitin has potent signaling functions and that its deregulation is connected to disease. Indeed, mutations and deficiencies in several factors involved in conjugation and deconjugation of Met1-linked polyubiquitin have been implicated in immune-related disorders. Here, we discuss current knowledge and recent insights into the role and regulation of Met1-linked polyubiquitin, with an emphasis on the mechanisms controlling the function of LUBAC.
KW - Animals
KW - Cell Death
KW - Humans
KW - Immunity
KW - NF-kappa B/genetics
KW - Neoplasm Proteins/immunology
KW - Neoplasms/immunology
KW - Polyubiquitin/genetics
KW - Signal Transduction
U2 - 10.1016/j.molcel.2017.09.001
DO - 10.1016/j.molcel.2017.09.001
M3 - Review
C2 - 29053955
VL - 68
SP - 265
EP - 280
JO - Molecular Cell
JF - Molecular Cell
SN - 1097-2765
IS - 2
ER -
ID: 280717758