The European COPHES/DEMOCOPHES project: Towards transnational comparability and reliability of human biomonitoring results
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The European COPHES/DEMOCOPHES project : Towards transnational comparability and reliability of human biomonitoring results. / Schindler, Birgit Karin; Esteban, Marta; Koch, Holger Martin; Castano, Argelia; Koslitz, Stephan; Cañas, Ana; Casteleyn, Ludwine; Kolossa-Gehring, Marike; Schwedler, Gerda; Schoeters, Greet; Hond, Elly Den; Sepai, Ovnair; Exley, Karen; Bloemen, Louis; Horvat, Milena; Knudsen, Lisbeth E; Joas, Anke; Joas, Reinhard; Biot, Pierre; Aerts, Dominique; Lopez, Ana; Huetos, Olga; Katsonouri, Andromachi; Maurer-Chronakis, Katja; Kasparova, Lucie; Vrbík, Karel; Rudnai, Peter; Naray, Miklos; Guignard, Cedric; Fischer, Marc E; Ligocka, Danuta; Janasik, Beata; Reis, M Fátima; Namorado, Sónia; Pop, Cristian; Dumitrascu, Irina; Halzlova, Katarina; Fabianova, Eleonora; Mazej, Darja; Tratnik, Janja Snoj; Berglund, Marika; Jönsson, Bo; Lehmann, Andrea; Crettaz, Pierre; Frederiksen, Hanne; Nielsen, Flemming; McGrath, Helena; Nesbitt, Ian; De Cremer, Koen; Vanermen, Guido; Koppen, Gudrun; Wilhelm, Michael; Becker, Kerstin; Angerer, Jürgen.
In: International Journal of Hygiene and Environmental Health, Vol. 217, No. 6, 07.2014, p. 653-61.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The European COPHES/DEMOCOPHES project
T2 - Towards transnational comparability and reliability of human biomonitoring results
AU - Schindler, Birgit Karin
AU - Esteban, Marta
AU - Koch, Holger Martin
AU - Castano, Argelia
AU - Koslitz, Stephan
AU - Cañas, Ana
AU - Casteleyn, Ludwine
AU - Kolossa-Gehring, Marike
AU - Schwedler, Gerda
AU - Schoeters, Greet
AU - Hond, Elly Den
AU - Sepai, Ovnair
AU - Exley, Karen
AU - Bloemen, Louis
AU - Horvat, Milena
AU - Knudsen, Lisbeth E
AU - Joas, Anke
AU - Joas, Reinhard
AU - Biot, Pierre
AU - Aerts, Dominique
AU - Lopez, Ana
AU - Huetos, Olga
AU - Katsonouri, Andromachi
AU - Maurer-Chronakis, Katja
AU - Kasparova, Lucie
AU - Vrbík, Karel
AU - Rudnai, Peter
AU - Naray, Miklos
AU - Guignard, Cedric
AU - Fischer, Marc E
AU - Ligocka, Danuta
AU - Janasik, Beata
AU - Reis, M Fátima
AU - Namorado, Sónia
AU - Pop, Cristian
AU - Dumitrascu, Irina
AU - Halzlova, Katarina
AU - Fabianova, Eleonora
AU - Mazej, Darja
AU - Tratnik, Janja Snoj
AU - Berglund, Marika
AU - Jönsson, Bo
AU - Lehmann, Andrea
AU - Crettaz, Pierre
AU - Frederiksen, Hanne
AU - Nielsen, Flemming
AU - McGrath, Helena
AU - Nesbitt, Ian
AU - De Cremer, Koen
AU - Vanermen, Guido
AU - Koppen, Gudrun
AU - Wilhelm, Michael
AU - Becker, Kerstin
AU - Angerer, Jürgen
N1 - Copyright © 2013 Elsevier GmbH. All rights reserved.
PY - 2014/7
Y1 - 2014/7
N2 - COPHES/DEMOCOPHES has its origins in the European Environment and Health Action Plan of 2004 to "develop a coherent approach on human biomonitoring (HBM) in Europe". Within this twin-project it was targeted to collect specimens from 120 mother-child-pairs in each of the 17 participating European countries. These specimens were investigated for six biomarkers (mercury in hair; creatinine, cotinine, cadmium, phthalate metabolites and bisphenol A in urine). The results for mercury in hair are described in a separate paper. Each participating member state was requested to contract laboratories, for capacity building reasons ideally within its borders, carrying out the chemical analyses. To ensure comparability of analytical data a Quality Assurance Unit (QAU) was established which provided the participating laboratories with standard operating procedures (SOP) and with control material. This material was specially prepared from native, non-spiked, pooled urine samples and was tested for homogeneity and stability. Four external quality assessment exercises were carried out. Highly esteemed laboratories from all over the world served as reference laboratories. Web conferences after each external quality assessment exercise functioned as a new and effective tool to improve analytical performance, to build capacity and to educate less experienced laboratories. Of the 38 laboratories participating in the quality assurance exercises 14 laboratories qualified for cadmium, 14 for creatinine, 9 for cotinine, 7 for phthalate metabolites and 5 for bisphenol A in urine. In the last of the four external quality assessment exercises the laboratories that qualified for DEMOCOPHES performed the determinations in urine with relative standard deviations (low/high concentration) of 18.0/2.1% for cotinine, 14.8/5.1% for cadmium, 4.7/3.4% for creatinine. Relative standard deviations for the newly emerging biomarkers were higher, with values between 13.5 and 20.5% for bisphenol A and between 18.9 and 45.3% for the phthalate metabolites. Plausibility control of the HBM results of all participating countries disclosed analytical shortcomings in the determination of Cd when using certain ICP/MS methods. Results were corrected by reanalyzes. The COPHES/DEMOCOPHES project for the first time succeeded in performing a harmonized pan-European HBM project. All data raised have to be regarded as utmost reliable according to the highest international state of the art, since highly renowned laboratories functioned as reference laboratories. The procedure described here, that has shown its success, can be used as a blueprint for future transnational, multicentre HBM projects.
AB - COPHES/DEMOCOPHES has its origins in the European Environment and Health Action Plan of 2004 to "develop a coherent approach on human biomonitoring (HBM) in Europe". Within this twin-project it was targeted to collect specimens from 120 mother-child-pairs in each of the 17 participating European countries. These specimens were investigated for six biomarkers (mercury in hair; creatinine, cotinine, cadmium, phthalate metabolites and bisphenol A in urine). The results for mercury in hair are described in a separate paper. Each participating member state was requested to contract laboratories, for capacity building reasons ideally within its borders, carrying out the chemical analyses. To ensure comparability of analytical data a Quality Assurance Unit (QAU) was established which provided the participating laboratories with standard operating procedures (SOP) and with control material. This material was specially prepared from native, non-spiked, pooled urine samples and was tested for homogeneity and stability. Four external quality assessment exercises were carried out. Highly esteemed laboratories from all over the world served as reference laboratories. Web conferences after each external quality assessment exercise functioned as a new and effective tool to improve analytical performance, to build capacity and to educate less experienced laboratories. Of the 38 laboratories participating in the quality assurance exercises 14 laboratories qualified for cadmium, 14 for creatinine, 9 for cotinine, 7 for phthalate metabolites and 5 for bisphenol A in urine. In the last of the four external quality assessment exercises the laboratories that qualified for DEMOCOPHES performed the determinations in urine with relative standard deviations (low/high concentration) of 18.0/2.1% for cotinine, 14.8/5.1% for cadmium, 4.7/3.4% for creatinine. Relative standard deviations for the newly emerging biomarkers were higher, with values between 13.5 and 20.5% for bisphenol A and between 18.9 and 45.3% for the phthalate metabolites. Plausibility control of the HBM results of all participating countries disclosed analytical shortcomings in the determination of Cd when using certain ICP/MS methods. Results were corrected by reanalyzes. The COPHES/DEMOCOPHES project for the first time succeeded in performing a harmonized pan-European HBM project. All data raised have to be regarded as utmost reliable according to the highest international state of the art, since highly renowned laboratories functioned as reference laboratories. The procedure described here, that has shown its success, can be used as a blueprint for future transnational, multicentre HBM projects.
U2 - 10.1016/j.ijheh.2013.12.002
DO - 10.1016/j.ijheh.2013.12.002
M3 - Journal article
C2 - 24405937
VL - 217
SP - 653
EP - 661
JO - International Journal of Hygiene and Environmental Health
JF - International Journal of Hygiene and Environmental Health
SN - 1438-4639
IS - 6
ER -
ID: 117866778