The effects of post-operative oxygen supply on blood oxygenation and acid-base status in rats anaesthetized with fentanyl/fluanisone and midazolam

Research output: Contribution to journal › Journal article › Research › peer-review

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The effects of post-operative oxygen supply on blood oxygenation and acid-base status in rats anaesthetized with fentanyl/fluanisone and midazolam. / Gaarde, Leander; Kolstrup, Stefanie; Bollen, Peter.

In: PLoS ONE, Vol. 16, No. 8, e0255829, 2021.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Gaarde, L, Kolstrup, S & Bollen, P 2021, 'The effects of post-operative oxygen supply on blood oxygenation and acid-base status in rats anaesthetized with fentanyl/fluanisone and midazolam', PLoS ONE, vol. 16, no. 8, e0255829. https://doi.org/10.1371/journal.pone.0255829

APA

Gaarde, L., Kolstrup, S., & Bollen, P. (2021). The effects of post-operative oxygen supply on blood oxygenation and acid-base status in rats anaesthetized with fentanyl/fluanisone and midazolam. PLoS ONE, 16(8), [e0255829]. https://doi.org/10.1371/journal.pone.0255829

Vancouver

Gaarde L, Kolstrup S, Bollen P. The effects of post-operative oxygen supply on blood oxygenation and acid-base status in rats anaesthetized with fentanyl/fluanisone and midazolam. PLoS ONE. 2021;16(8). e0255829. https://doi.org/10.1371/journal.pone.0255829

Author

Gaarde, Leander ; Kolstrup, Stefanie ; Bollen, Peter. / The effects of post-operative oxygen supply on blood oxygenation and acid-base status in rats anaesthetized with fentanyl/fluanisone and midazolam. In: PLoS ONE. 2021 ; Vol. 16, No. 8.

Bibtex

@article{890b4475a36546ffb9306d309faeb4ea,
title = "The effects of post-operative oxygen supply on blood oxygenation and acid-base status in rats anaesthetized with fentanyl/fluanisone and midazolam",
abstract = "In anaesthetic practice the risk of hypoxia and arterial blood gas disturbances is evident, as most anaesthetic regimens depress the respiratory function. Hypoxia may be extended during recovery, and for this reason we wished to investigate if oxygen supply during a one hour post-operative period reduced the development of hypoxia and respiratory acidosis in rats anaesthetized with fentanyl/fluanisone and midazolam. Twelve Sprague Dawley rats underwent surgery and were divided in two groups, breathing either 100% oxygen or atmospheric air during a post-operative period. The peripheral blood oxygen saturation and arterial acid-base status were analyzed for differences between the two groups. We found that oxygen supply after surgery prevented hypoxia but did not result in a significant difference in the blood acid-base status. All rats developed respiratory acidosis, which could not be reversed by supplemental oxygen supply. We concluded that oxygen supply improved oxygen saturation and avoided hypoxia but did not have an influence on the acid-base status.",
keywords = "Animals, Butyrophenones, Fentanyl, Male, Midazolam, Rats",
author = "Leander Gaarde and Stefanie Kolstrup and Peter Bollen",
year = "2021",
doi = "10.1371/journal.pone.0255829",
language = "English",
volume = "16",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "8",

}

RIS

TY - JOUR

T1 - The effects of post-operative oxygen supply on blood oxygenation and acid-base status in rats anaesthetized with fentanyl/fluanisone and midazolam

AU - Gaarde, Leander

AU - Kolstrup, Stefanie

AU - Bollen, Peter

PY - 2021

Y1 - 2021

N2 - In anaesthetic practice the risk of hypoxia and arterial blood gas disturbances is evident, as most anaesthetic regimens depress the respiratory function. Hypoxia may be extended during recovery, and for this reason we wished to investigate if oxygen supply during a one hour post-operative period reduced the development of hypoxia and respiratory acidosis in rats anaesthetized with fentanyl/fluanisone and midazolam. Twelve Sprague Dawley rats underwent surgery and were divided in two groups, breathing either 100% oxygen or atmospheric air during a post-operative period. The peripheral blood oxygen saturation and arterial acid-base status were analyzed for differences between the two groups. We found that oxygen supply after surgery prevented hypoxia but did not result in a significant difference in the blood acid-base status. All rats developed respiratory acidosis, which could not be reversed by supplemental oxygen supply. We concluded that oxygen supply improved oxygen saturation and avoided hypoxia but did not have an influence on the acid-base status.

AB - In anaesthetic practice the risk of hypoxia and arterial blood gas disturbances is evident, as most anaesthetic regimens depress the respiratory function. Hypoxia may be extended during recovery, and for this reason we wished to investigate if oxygen supply during a one hour post-operative period reduced the development of hypoxia and respiratory acidosis in rats anaesthetized with fentanyl/fluanisone and midazolam. Twelve Sprague Dawley rats underwent surgery and were divided in two groups, breathing either 100% oxygen or atmospheric air during a post-operative period. The peripheral blood oxygen saturation and arterial acid-base status were analyzed for differences between the two groups. We found that oxygen supply after surgery prevented hypoxia but did not result in a significant difference in the blood acid-base status. All rats developed respiratory acidosis, which could not be reversed by supplemental oxygen supply. We concluded that oxygen supply improved oxygen saturation and avoided hypoxia but did not have an influence on the acid-base status.

KW - Animals

KW - Butyrophenones

KW - Fentanyl

KW - Male

KW - Midazolam

KW - Rats

U2 - 10.1371/journal.pone.0255829

DO - 10.1371/journal.pone.0255829

M3 - Journal article

C2 - 34370776

VL - 16

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 8

M1 - e0255829

ER -

ID: 316213754