The effect of melatonin on sleep quality after laparoscopic cholecystectomy: a randomized, placebo-controlled trial
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The effect of melatonin on sleep quality after laparoscopic cholecystectomy: a randomized, placebo-controlled trial. / Gögenur, Ismail; Kücükakin, Bülent; Bisgaard, Thue; Kristiansen, Viggo; Hjortsø, Niels-Christian; Skene, Debra J; Rosenberg, Jacob.
In: Anesthesia and Analgesia, Vol. 108, No. 4, 2009, p. 1152-6.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The effect of melatonin on sleep quality after laparoscopic cholecystectomy: a randomized, placebo-controlled trial
AU - Gögenur, Ismail
AU - Kücükakin, Bülent
AU - Bisgaard, Thue
AU - Kristiansen, Viggo
AU - Hjortsø, Niels-Christian
AU - Skene, Debra J
AU - Rosenberg, Jacob
N1 - Keywords: Administration, Oral; Adult; Ambulatory Surgical Procedures; Cholecystectomy, Laparoscopic; Double-Blind Method; Drug Administration Schedule; Fatigue; Female; Humans; Hypnotics and Sedatives; Male; Melatonin; Middle Aged; Pain Measurement; Pain, Postoperative; Sleep; Surgical Procedures, Elective; Time Factors; Treatment Outcome
PY - 2009
Y1 - 2009
N2 - BACKGROUND: In this study, we investigated whether melatonin administration could improve postoperative subjective sleep quality and reduce discomfort. METHODS: One hundred twenty-one patients scheduled for elective ambulatory laparoscopic cholecystectomy were randomized to oral 5 mg melatonin (n = 60) or placebo (n = 61) for 3 nights after surgery. Subjective sleep quality, sleep duration, sleep timing, and subjective discomfort (fatigue, general well-being, and pain) were measured. RESULTS: Sleep latency was significantly reduced in the melatonin group (mean [sd] 14 min [18]) compared with placebo (28 min [41]) on the first postoperative night (P = 0.015). The rest of the measured outcome variables did not differ between groups. CONCLUSIONS: Melatonin did not improve subjective sleep quality or discomfort compared with placebo after laparoscopic cholecystectomy.
AB - BACKGROUND: In this study, we investigated whether melatonin administration could improve postoperative subjective sleep quality and reduce discomfort. METHODS: One hundred twenty-one patients scheduled for elective ambulatory laparoscopic cholecystectomy were randomized to oral 5 mg melatonin (n = 60) or placebo (n = 61) for 3 nights after surgery. Subjective sleep quality, sleep duration, sleep timing, and subjective discomfort (fatigue, general well-being, and pain) were measured. RESULTS: Sleep latency was significantly reduced in the melatonin group (mean [sd] 14 min [18]) compared with placebo (28 min [41]) on the first postoperative night (P = 0.015). The rest of the measured outcome variables did not differ between groups. CONCLUSIONS: Melatonin did not improve subjective sleep quality or discomfort compared with placebo after laparoscopic cholecystectomy.
U2 - 10.1213/ane.0b013e31819a6cf0
DO - 10.1213/ane.0b013e31819a6cf0
M3 - Journal article
C2 - 19299778
VL - 108
SP - 1152
EP - 1156
JO - Anesthesia and Analgesia
JF - Anesthesia and Analgesia
SN - 0003-2999
IS - 4
ER -
ID: 19440825