The effect of long-term treatment with coenzyme Q10 on nucleic acid modifications by oxidation in children with Down syndrome
Research output: Contribution to journal › Journal article › Research › peer-review
Elevated levels of oxidative nucleic acid modifications have been proposed to be associated with some of the clinical characteristics of Down syndrome. Oral intake of coenzyme Q10 improves oxidative status and shows a tendency toward protective effect on DNA oxidation in certain age groups of children with Down syndrome. Here, we demonstrate that long-term (i.e., 4 years) treatment with coenzyme Q10 (ubiquinone) at the dosage of 4 mg/kg/d does not affect whole body DNA and RNA oxidation.
Original language | English |
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Journal | Neurobiology of Aging |
Volume | 67 |
Pages (from-to) | 159-161 |
ISSN | 0197-4580 |
DOIs | |
Publication status | Published - 2018 |
- Administration, Oral, Biomarkers/urine, Child, DNA/metabolism, Deoxyadenosines/urine, Down Syndrome/drug therapy, Guanine/analogs & derivatives, Humans, Oxidation-Reduction/drug effects, Oxidative Stress/drug effects, RNA/metabolism, Time Factors, Ubiquinone/administration & dosage
Research areas
ID: 212907807