The effect of EDTA and metal cations on the 5-bromoindoxyl acetate esterase activity in the thyroid of the guinea-pig
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The effect of EDTA and metal cations on the 5-bromoindoxyl acetate esterase activity in the thyroid of the guinea-pig. / Kirkeby, S.
In: The Histochemical Journal, Vol. 8, No. 5, 1976, p. 463-770.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The effect of EDTA and metal cations on the 5-bromoindoxyl acetate esterase activity in the thyroid of the guinea-pig
AU - Kirkeby, S
N1 - Keywords: Animals; Calcium; Cobalt; Edetic Acid; Enzyme Activation; Esterases; Guinea Pigs; Histocytochemistry; Magnesium; Manganese; Staining and Labeling; Thyroid Gland; Zinc
PY - 1976
Y1 - 1976
N2 - Miscellaneous metal cations and EDTA have been used as activators and inhibitors of esterase activity in the thyroid of the guinea-pig. The results indicate that the 5-bromoiondoxyl acetate esterase in the epithelial cells probably consists of two different A-esterase isoenzymes, one present in group I cells (the para-, intra-, and inter-follicular cells) and the other in group II cells (the follicular cells proper). The first isoenzyme seems to be calcium-dependent whereas the other is activated by various metal ions. Ca2+ + Mn2+ and Ca2+ + Co2+ were found to activate the esterase activity in group I cells. EDTA and Mn2+, on the other hand, activated the esterase activity in group II cells.
AB - Miscellaneous metal cations and EDTA have been used as activators and inhibitors of esterase activity in the thyroid of the guinea-pig. The results indicate that the 5-bromoiondoxyl acetate esterase in the epithelial cells probably consists of two different A-esterase isoenzymes, one present in group I cells (the para-, intra-, and inter-follicular cells) and the other in group II cells (the follicular cells proper). The first isoenzyme seems to be calcium-dependent whereas the other is activated by various metal ions. Ca2+ + Mn2+ and Ca2+ + Co2+ were found to activate the esterase activity in group I cells. EDTA and Mn2+, on the other hand, activated the esterase activity in group II cells.
M3 - Journal article
C2 - 61192
VL - 8
SP - 463
EP - 770
JO - The Histochemical Journal
JF - The Histochemical Journal
SN - 0018-2214
IS - 5
ER -
ID: 10026736