The antiinflammatory moiety of sulfasalazine, 5-aminosalicylic acid, is a radical scavenger
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The antiinflammatory moiety of sulfasalazine, 5-aminosalicylic acid, is a radical scavenger. / Ahnfelt-Rønne, I; Nielsen, O H.
In: Agents and Actions, Vol. 21, No. 1-2, 06.1987, p. 191-4.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The antiinflammatory moiety of sulfasalazine, 5-aminosalicylic acid, is a radical scavenger
AU - Ahnfelt-Rønne, I
AU - Nielsen, O H
PY - 1987/6
Y1 - 1987/6
N2 - Using a novel spectrophotometric assay to detect free radical scavengers, the effects of sulfasalazine, a compound frequently administered in the treatment of chronic inflammatory bowel disease, and its main metabolites, 5-aminosalicylic acid (5-ASA), sulfapyridine, and N-acetyl-5-ASA, were compared with biological antioxidants (nordihydroguaiaretic acid (NDGA), alpha-tocopherol, and ascorbic acid) and antiinflammatory salicylates (acetylsalicylic acid and sodium salicylate). The results show that 5-ASA, but neither sulfasalazine and its other metabolites, nor the salicylates, shares with the biological antioxidants the property of being a potent scavenger of free radicals. Since 5-ASA is formed in millimolar concentrations in the colon of sulfasalazine-treated patients this mode of action may explain the beneficial effect of sulfasalazine in inflammatory bowel disease. Locally formed 5-ASA may break the free radical chain reaction initiated and maintained by activated phagocytes, thus arresting the perpetuating tissue destruction. This mechanism may indicate a general potential for radical scavengers in chronic inflammation.
AB - Using a novel spectrophotometric assay to detect free radical scavengers, the effects of sulfasalazine, a compound frequently administered in the treatment of chronic inflammatory bowel disease, and its main metabolites, 5-aminosalicylic acid (5-ASA), sulfapyridine, and N-acetyl-5-ASA, were compared with biological antioxidants (nordihydroguaiaretic acid (NDGA), alpha-tocopherol, and ascorbic acid) and antiinflammatory salicylates (acetylsalicylic acid and sodium salicylate). The results show that 5-ASA, but neither sulfasalazine and its other metabolites, nor the salicylates, shares with the biological antioxidants the property of being a potent scavenger of free radicals. Since 5-ASA is formed in millimolar concentrations in the colon of sulfasalazine-treated patients this mode of action may explain the beneficial effect of sulfasalazine in inflammatory bowel disease. Locally formed 5-ASA may break the free radical chain reaction initiated and maintained by activated phagocytes, thus arresting the perpetuating tissue destruction. This mechanism may indicate a general potential for radical scavengers in chronic inflammation.
KW - Anti-Inflammatory Agents, Non-Steroidal/pharmacology
KW - Antioxidants/pharmacology
KW - Biphenyl Compounds
KW - Free Radicals
KW - Hydrazines/metabolism
KW - Oxidation-Reduction
KW - Picrates
KW - Salicylates/pharmacology
KW - Spectrophotometry
KW - Sulfasalazine/metabolism
M3 - Journal article
C2 - 2888280
VL - 21
SP - 191
EP - 194
JO - Agents and Actions
JF - Agents and Actions
SN - 0065-4299
IS - 1-2
ER -
ID: 218730040