The activity of non-specific esterase in the thyroid epithelial cells of the guinea pig as influenced by various inhibitors and activators: A histochemical study
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The activity of non-specific esterase in the thyroid epithelial cells of the guinea pig as influenced by various inhibitors and activators : A histochemical study. / Kirkeby, S.
In: Histochemistry, Vol. 48, No. 1, 1976, p. 51-60.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The activity of non-specific esterase in the thyroid epithelial cells of the guinea pig as influenced by various inhibitors and activators
T2 - A histochemical study
AU - Kirkeby, S.
N1 - Keywords: Acetylesterase; Animals; Carbamates; Chloromercuribenzoates; Esterases; Guinea Pigs; Histocytochemistry; Thyroid Gland; Tritolyl Phosphates
PY - 1976
Y1 - 1976
N2 - The action of various inhibitors and activators upon esterase activity in the thyroid epithelial cells is demonstrated. The agents used were triorthocresylphosphate (TOCP), parachloromercuribenzoate (PCMB), Arsanillic acid, p-nitrophenyl dimethyl carbamate and bis p-nitrophenyl phosphate. TOCP was found to inhibit selectively the activity in the follicle cells proper when alpha naphthyl acetate was used as a substrate. Arsanillic acid (0,001 M) activated the follicle cells proper selectively, but if the concentration was raised to 0,01 M the effect was that of inhibition while the activity in the para-, inter- and intrafollicular cells was unchanged. The results obtained are related to previous biochemical and histochemical observations and the nature of esterases in the thyroid is discussed.
AB - The action of various inhibitors and activators upon esterase activity in the thyroid epithelial cells is demonstrated. The agents used were triorthocresylphosphate (TOCP), parachloromercuribenzoate (PCMB), Arsanillic acid, p-nitrophenyl dimethyl carbamate and bis p-nitrophenyl phosphate. TOCP was found to inhibit selectively the activity in the follicle cells proper when alpha naphthyl acetate was used as a substrate. Arsanillic acid (0,001 M) activated the follicle cells proper selectively, but if the concentration was raised to 0,01 M the effect was that of inhibition while the activity in the para-, inter- and intrafollicular cells was unchanged. The results obtained are related to previous biochemical and histochemical observations and the nature of esterases in the thyroid is discussed.
U2 - 10.1007/BF00489716
DO - 10.1007/BF00489716
M3 - Journal article
C2 - 993058
VL - 48
SP - 51
EP - 60
JO - Histochemistry
JF - Histochemistry
SN - 0301-5564
IS - 1
ER -
ID: 10026761