Temporal dynamics of woolly mammoth genome erosion prior to extinction
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Temporal dynamics of woolly mammoth genome erosion prior to extinction. / Dehasque, Marianne; Morales, Hernán E.; Díez-del-Molino, David; Pečnerová, Patrícia; Chacón-Duque, J. Camilo; Kanellidou, Foteini; Muller, Héloïse; Plotnikov, Valerii; Protopopov, Albert; Tikhonov, Alexei; Nikolskiy, Pavel; Danilov, Gleb K.; Giannì, Maddalena; van der Sluis, Laura; Higham, Tom; Heintzman, Peter D.; Oskolkov, Nikolay; Gilbert, M. Thomas P.; Götherström, Anders; van der Valk, Tom; Vartanyan, Sergey; Dalén, Love.
In: Cell, Vol. 187, No. 14, 2024, p. 3531-3540.e13.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Temporal dynamics of woolly mammoth genome erosion prior to extinction
AU - Dehasque, Marianne
AU - Morales, Hernán E.
AU - Díez-del-Molino, David
AU - Pečnerová, Patrícia
AU - Chacón-Duque, J. Camilo
AU - Kanellidou, Foteini
AU - Muller, Héloïse
AU - Plotnikov, Valerii
AU - Protopopov, Albert
AU - Tikhonov, Alexei
AU - Nikolskiy, Pavel
AU - Danilov, Gleb K.
AU - Giannì, Maddalena
AU - van der Sluis, Laura
AU - Higham, Tom
AU - Heintzman, Peter D.
AU - Oskolkov, Nikolay
AU - Gilbert, M. Thomas P.
AU - Götherström, Anders
AU - van der Valk, Tom
AU - Vartanyan, Sergey
AU - Dalén, Love
N1 - Publisher Copyright: © 2024 The Author(s)
PY - 2024
Y1 - 2024
N2 - A number of species have recently recovered from near-extinction. Although these species have avoided the immediate extinction threat, their long-term viability remains precarious due to the potential genetic consequences of population declines, which are poorly understood on a timescale beyond a few generations. Woolly mammoths (Mammuthus primigenius) became isolated on Wrangel Island around 10,000 years ago and persisted for over 200 generations before becoming extinct around 4,000 years ago. To study the evolutionary processes leading up to the mammoths’ extinction, we analyzed 21 Siberian woolly mammoth genomes. Our results show that the population recovered quickly from a severe bottleneck and remained demographically stable during the ensuing six millennia. We find that mildly deleterious mutations gradually accumulated, whereas highly deleterious mutations were purged, suggesting ongoing inbreeding depression that lasted for hundreds of generations. The time-lag between demographic and genetic recovery has wide-ranging implications for conservation management of recently bottlenecked populations.
AB - A number of species have recently recovered from near-extinction. Although these species have avoided the immediate extinction threat, their long-term viability remains precarious due to the potential genetic consequences of population declines, which are poorly understood on a timescale beyond a few generations. Woolly mammoths (Mammuthus primigenius) became isolated on Wrangel Island around 10,000 years ago and persisted for over 200 generations before becoming extinct around 4,000 years ago. To study the evolutionary processes leading up to the mammoths’ extinction, we analyzed 21 Siberian woolly mammoth genomes. Our results show that the population recovered quickly from a severe bottleneck and remained demographically stable during the ensuing six millennia. We find that mildly deleterious mutations gradually accumulated, whereas highly deleterious mutations were purged, suggesting ongoing inbreeding depression that lasted for hundreds of generations. The time-lag between demographic and genetic recovery has wide-ranging implications for conservation management of recently bottlenecked populations.
KW - ancient DNA
KW - bottleneck
KW - climate
KW - extinction
KW - inbreeding
KW - Mammuthus primigenius
KW - mutation load
KW - paleogenomics
KW - woolly mammoth
KW - Wrangel Island
UR - http://www.scopus.com/inward/record.url?scp=85197516018&partnerID=8YFLogxK
U2 - 10.1016/j.cell.2024.05.033
DO - 10.1016/j.cell.2024.05.033
M3 - Journal article
C2 - 38942016
AN - SCOPUS:85197516018
VL - 187
SP - 3531-3540.e13
JO - Cell
JF - Cell
SN - 0092-8674
IS - 14
ER -
ID: 398475608