Standard
Targeted delivery of alcohol-containing payloads with antibody-drug conjugates. / Grier, Katja E; Hansen, Anders H; Haxvig, Christina S.; Li, Xin; Krigslund, Oliver; Behrendt, Niels; Engelholm, Lars H; Rossi, Fabio; Sousa, Bebiana C; Harradence, Grant J; Camper, Nicolas; Qvortrup, Katrine M.
In:
Chemical Communications, Vol. 59, No. 47, 2023, p. 7240-7242.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Grier, KE, Hansen, AH, Haxvig, CS
, Li, X, Krigslund, O
, Behrendt, N, Engelholm, LH, Rossi, F, Sousa, BC, Harradence, GJ, Camper, N & Qvortrup, KM 2023, '
Targeted delivery of alcohol-containing payloads with antibody-drug conjugates',
Chemical Communications, vol. 59, no. 47, pp. 7240-7242.
https://doi.org/10.1039/d3cc01596c
APA
Grier, K. E., Hansen, A. H., Haxvig, C. S.
, Li, X., Krigslund, O.
, Behrendt, N., Engelholm, L. H., Rossi, F., Sousa, B. C., Harradence, G. J., Camper, N., & Qvortrup, K. M. (2023).
Targeted delivery of alcohol-containing payloads with antibody-drug conjugates.
Chemical Communications,
59(47), 7240-7242.
https://doi.org/10.1039/d3cc01596c
Vancouver
Grier KE, Hansen AH, Haxvig CS
, Li X, Krigslund O
, Behrendt N et al.
Targeted delivery of alcohol-containing payloads with antibody-drug conjugates.
Chemical Communications. 2023;59(47):7240-7242.
https://doi.org/10.1039/d3cc01596c
Author
Grier, Katja E ; Hansen, Anders H ; Haxvig, Christina S. ; Li, Xin ; Krigslund, Oliver ; Behrendt, Niels ; Engelholm, Lars H ; Rossi, Fabio ; Sousa, Bebiana C ; Harradence, Grant J ; Camper, Nicolas ; Qvortrup, Katrine M. / Targeted delivery of alcohol-containing payloads with antibody-drug conjugates. In: Chemical Communications. 2023 ; Vol. 59, No. 47. pp. 7240-7242.
Bibtex
@article{518f3b25405a45b0a8ba4699ee376c1d,
title = "Targeted delivery of alcohol-containing payloads with antibody-drug conjugates",
abstract = "We herein describe the cell-specific release of alcohol-containing payloads via a sulfatase-sensitive linker in antibody-drug conjugates (ADCs). The linker shows efficient sulfatase-mediated release and high stability in human and mouse plasma. In vitro evaluation demonstrates potent antigen dependent toxicity towards breast cancer cell lines. ",
author = "Grier, {Katja E} and Hansen, {Anders H} and Haxvig, {Christina S.} and Xin Li and Oliver Krigslund and Niels Behrendt and Engelholm, {Lars H} and Fabio Rossi and Sousa, {Bebiana C} and Harradence, {Grant J} and Nicolas Camper and Qvortrup, {Katrine M.}",
year = "2023",
doi = "10.1039/d3cc01596c",
language = "English",
volume = "59",
pages = "7240--7242",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "47",
}
RIS
TY - JOUR
T1 - Targeted delivery of alcohol-containing payloads with antibody-drug conjugates
AU - Grier, Katja E
AU - Hansen, Anders H
AU - Haxvig, Christina S.
AU - Li, Xin
AU - Krigslund, Oliver
AU - Behrendt, Niels
AU - Engelholm, Lars H
AU - Rossi, Fabio
AU - Sousa, Bebiana C
AU - Harradence, Grant J
AU - Camper, Nicolas
AU - Qvortrup, Katrine M.
PY - 2023
Y1 - 2023
N2 - We herein describe the cell-specific release of alcohol-containing payloads
via a sulfatase-sensitive linker in antibody-drug conjugates (ADCs). The linker shows efficient sulfatase-mediated release and high stability in human and mouse plasma.
In vitro evaluation demonstrates potent antigen dependent toxicity towards breast cancer cell lines.
AB - We herein describe the cell-specific release of alcohol-containing payloads
via a sulfatase-sensitive linker in antibody-drug conjugates (ADCs). The linker shows efficient sulfatase-mediated release and high stability in human and mouse plasma.
In vitro evaluation demonstrates potent antigen dependent toxicity towards breast cancer cell lines.
U2 - 10.1039/d3cc01596c
DO - 10.1039/d3cc01596c
M3 - Journal article
C2 - 37222285
VL - 59
SP - 7240
EP - 7242
JO - Chemical Communications
JF - Chemical Communications
SN - 1359-7345
IS - 47
ER -