Target intervention against multiple-risk markers to reduce cardiovascular disease in patients with type 2 diabetes
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Target intervention against multiple-risk markers to reduce cardiovascular disease in patients with type 2 diabetes. / Gaede, Peter; Pedersen, Oluf.
In: Annals of Medicine, Vol. 36, No. 5, 2004, p. 355-66.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Target intervention against multiple-risk markers to reduce cardiovascular disease in patients with type 2 diabetes
AU - Gaede, Peter
AU - Pedersen, Oluf
PY - 2004
Y1 - 2004
N2 - The risk of cardiovascular disease is markedly increased in patients with type 2 diabetes with a prevalence twice as high compared to the background population. With the recognition of multiple concomitant risk factors for both microvascular as well as cardiovascular disease in type 2 diabetic patients, treatment strategies have changed during recent years. This review focuses on the many recent drug trials that have set the course for an effective multifactorial treatment of the disease. Thus, the Steno-2 Study has shown that an intensified multifactorial intervention targeting several risk factors for cardiovascular disease is capable of reducing the risk for a combined endpoint of cardiovascular mortality, non-fatal myocardial infarction, non-fatal stroke, coronary interventions, revascularisation to legs, and amputations by 50%.
AB - The risk of cardiovascular disease is markedly increased in patients with type 2 diabetes with a prevalence twice as high compared to the background population. With the recognition of multiple concomitant risk factors for both microvascular as well as cardiovascular disease in type 2 diabetic patients, treatment strategies have changed during recent years. This review focuses on the many recent drug trials that have set the course for an effective multifactorial treatment of the disease. Thus, the Steno-2 Study has shown that an intensified multifactorial intervention targeting several risk factors for cardiovascular disease is capable of reducing the risk for a combined endpoint of cardiovascular mortality, non-fatal myocardial infarction, non-fatal stroke, coronary interventions, revascularisation to legs, and amputations by 50%.
KW - Albuminuria
KW - Angiotensin-Converting Enzyme Inhibitors
KW - Cardiovascular Diseases
KW - Clinical Trials as Topic
KW - Diabetes Mellitus, Type 2
KW - Exercise
KW - Humans
KW - Hyperglycemia
KW - Hyperlipidemias
KW - Hypertension
KW - Risk Factors
KW - Smoking Cessation
M3 - Journal article
C2 - 15478310
VL - 36
SP - 355
EP - 366
JO - Medical Biology
JF - Medical Biology
SN - 0785-3890
IS - 5
ER -
ID: 38457160