T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis
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T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis. / Hedegaard, Chris J; Krakauer, Martin; Bendtzen, Klaus; Lund, Henrik; Sellebjerg, Finn; Nielsen, Claus H.
In: Immunology, Vol. 125, No. 2, 01.10.2008, p. 161-9.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - T helper cell type 1 (Th1), Th2 and Th17 responses to myelin basic protein and disease activity in multiple sclerosis
AU - Hedegaard, Chris J
AU - Krakauer, Martin
AU - Bendtzen, Klaus
AU - Lund, Henrik
AU - Sellebjerg, Finn
AU - Nielsen, Claus H
PY - 2008/10/1
Y1 - 2008/10/1
N2 - Autoreactive T cells are thought to play an essential role in the pathogenesis of multiple sclerosis (MS). We examined the stimulatory effect of human myelin basic protein (MBP) on mononuclear cell (MNC) cultures from 22 patients with MS and 22 sex-matched and age-matched healthy individuals, and related the patient responses to disease activity, as indicated by magnetic resonance imaging. The MBP induced a dose-dependent release of interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) by patient-derived MNCs. The patients' cells produced higher amounts of IFN-gamma and TNF-alpha, and lower amounts of IL-10, than cells from healthy controls (P
AB - Autoreactive T cells are thought to play an essential role in the pathogenesis of multiple sclerosis (MS). We examined the stimulatory effect of human myelin basic protein (MBP) on mononuclear cell (MNC) cultures from 22 patients with MS and 22 sex-matched and age-matched healthy individuals, and related the patient responses to disease activity, as indicated by magnetic resonance imaging. The MBP induced a dose-dependent release of interferon-gamma (IFN-gamma), tumour necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) by patient-derived MNCs. The patients' cells produced higher amounts of IFN-gamma and TNF-alpha, and lower amounts of IL-10, than cells from healthy controls (P
U2 - 10.1111/j.1365-2567.2008.02837.x
DO - 10.1111/j.1365-2567.2008.02837.x
M3 - Journal article
C2 - 18397264
VL - 125
SP - 161
EP - 169
JO - Immunology
JF - Immunology
SN - 0019-2805
IS - 2
ER -
ID: 10153167