Sympathetic vasoconstriction takes an unexpected pannexin detour
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Sympathetic vasoconstriction takes an unexpected pannexin detour. / Schak Nielsen, Morten.
In: Science Signaling, Vol. 8, No. 364, fs4, 17.02.2015, p. 1-2.Research output: Contribution to journal › Comment/debate › Research › peer-review
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TY - JOUR
T1 - Sympathetic vasoconstriction takes an unexpected pannexin detour
AU - Schak Nielsen, Morten
N1 - Copyright © 2015, American Association for the Advancement of Science.
PY - 2015/2/17
Y1 - 2015/2/17
N2 - Sympathetic vasoconstriction plays an important role in the control of blood pressure and the distribution of blood flow. In this issue of Science Signaling, Billaud et al. show that sympathetic vasoconstriction occurs through a complex scheme involving the activation of large-pore pannexin 1 channels and the subsequent release of adenosine triphosphate that promotes contraction in an autocrine and paracrine manner. This elaborate mechanism may function as a point of intercept for other signaling pathways-for example, in relation to the phenomenon "functional sympatholysis," in which exercise abrogates sympathetic vasoconstriction in skeletal muscle. Because pannexin 1 channels are inhibited by nitric oxide, they may function as a switch to turn off adrenergic signaling in skeletal muscle during exercise.
AB - Sympathetic vasoconstriction plays an important role in the control of blood pressure and the distribution of blood flow. In this issue of Science Signaling, Billaud et al. show that sympathetic vasoconstriction occurs through a complex scheme involving the activation of large-pore pannexin 1 channels and the subsequent release of adenosine triphosphate that promotes contraction in an autocrine and paracrine manner. This elaborate mechanism may function as a point of intercept for other signaling pathways-for example, in relation to the phenomenon "functional sympatholysis," in which exercise abrogates sympathetic vasoconstriction in skeletal muscle. Because pannexin 1 channels are inhibited by nitric oxide, they may function as a switch to turn off adrenergic signaling in skeletal muscle during exercise.
U2 - 10.1126/scisignal.aaa7312
DO - 10.1126/scisignal.aaa7312
M3 - Comment/debate
C2 - 25690011
VL - 8
SP - 1
EP - 2
JO - Science Signaling
JF - Science Signaling
SN - 1945-0877
IS - 364
M1 - fs4
ER -
ID: 131539236