Sub-chronic lung inflammation after airway exposures to Bacillus thuringiensis biopesticides in mice
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Sub-chronic lung inflammation after airway exposures to Bacillus thuringiensis biopesticides in mice. / Barfod, Kenneth K; Poulsen, Steen Seier; Hammer, Maria; Larsen, Søren T.
In: B M C Microbiology, Vol. 10, 03.09.2010, p. 233.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Sub-chronic lung inflammation after airway exposures to Bacillus thuringiensis biopesticides in mice
AU - Barfod, Kenneth K
AU - Poulsen, Steen Seier
AU - Hammer, Maria
AU - Larsen, Søren T.
PY - 2010/9/3
Y1 - 2010/9/3
N2 - The aim of the present study was to assess possible health effects of airway exposures to Bacillus thuringiensis (Bt) based biopesticides in mice. Endpoints were lung inflammation evaluated by presence of inflammatory cells in bronchoalveolar lavage fluid (BALF), clearance of bacteria from the lung lumen and histological alterations of the lungs. Hazard identifications of the biopesticides were carried out using intratracheal (i.t.) instillation, followed by an inhalation study. The two commercial biopesticides used were based on the Bt. subspecies kurstaki and israelensis, respectively. Groups of BALB/c mice were i.t instilled with one bolus (3.5 × 105 or 3.4 × 106 colony forming units (CFU) per mouse) of either biopesticide. Control mice were instilled with sterile water. BALFs were collected and the inflammatory cells were counted and differentiated. The BALFs were also subjected to CFU counts.
AB - The aim of the present study was to assess possible health effects of airway exposures to Bacillus thuringiensis (Bt) based biopesticides in mice. Endpoints were lung inflammation evaluated by presence of inflammatory cells in bronchoalveolar lavage fluid (BALF), clearance of bacteria from the lung lumen and histological alterations of the lungs. Hazard identifications of the biopesticides were carried out using intratracheal (i.t.) instillation, followed by an inhalation study. The two commercial biopesticides used were based on the Bt. subspecies kurstaki and israelensis, respectively. Groups of BALB/c mice were i.t instilled with one bolus (3.5 × 105 or 3.4 × 106 colony forming units (CFU) per mouse) of either biopesticide. Control mice were instilled with sterile water. BALFs were collected and the inflammatory cells were counted and differentiated. The BALFs were also subjected to CFU counts.
KW - Animals
KW - Bacillus thuringiensis
KW - Bronchoalveolar Lavage Fluid
KW - Female
KW - Humans
KW - Inhalation Exposure
KW - Lung
KW - Mice
KW - Mice, Inbred BALB C
KW - Models, Animal
KW - Pest Control, Biological
KW - Pesticides
KW - Respiratory System
U2 - 10.1186/1471-2180-10-233
DO - 10.1186/1471-2180-10-233
M3 - Journal article
C2 - 20815884
VL - 10
SP - 233
JO - BMC Microbiology
JF - BMC Microbiology
SN - 1471-2180
ER -
ID: 33792411