Study of the structure and impact of human leukocyte antigen (HLA)-G-A, HLA-G-B, and HLA-G-DRB1 haplotypes in families with recurrent miscarriage
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Study of the structure and impact of human leukocyte antigen (HLA)-G-A, HLA-G-B, and HLA-G-DRB1 haplotypes in families with recurrent miscarriage. / Kolte, Astrid M; Steffensen, Rudi; Nielsen, Henriette S; Hviid, Thomas V; Christiansen, Ole B.
In: Human Immunology, Vol. 71, No. 5, 05.2010, p. 482-8.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Study of the structure and impact of human leukocyte antigen (HLA)-G-A, HLA-G-B, and HLA-G-DRB1 haplotypes in families with recurrent miscarriage
AU - Kolte, Astrid M
AU - Steffensen, Rudi
AU - Nielsen, Henriette S
AU - Hviid, Thomas V
AU - Christiansen, Ole B
N1 - Copyright 2010 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
PY - 2010/5
Y1 - 2010/5
N2 - A 14-base pair (bp) long insertion (ins)/deletion (del) polymorphism in exon 8 in the 3'-untranslated region of the human leukocyte antigen (HLA)-G gene is suggested to affect transcription of the gene. Carriage of the G14bp ins is associated with low levels of soluble HLA-G and increases the risk of recurrent miscarriage (RM). Due to existence of strong linkage disequilibrium (LD) in the HLA region, the primary susceptibility genes for RM in the HLA-G region have not yet been identified. HLA-A, -B, -DRB1, and -G14bp polymorphisms were investigated in 29 Caucasian families with two or more siblings suffering unexplained RM. Strong positive LD was detected between the G14bp ins and HLA-A*01, -A*11, -A*31, -B*08, and DRB1*03, whereas strong negative LD was found between G14bp ins and HLA-A*02, -A*03, and -A*24. The frequency of haplotypes with HLA-G14bp ins inherited from the mother was significantly increased in probands with RM (p = 0.05). The increased compatibility between probands and their mothers for maternal G14 ins positive haplotypes suggests that maternal-fetal compatibility for chromosomal segments adjacent to HLA-G locus is a risk factor for female offspring to experience RM in their later reproductive life.
AB - A 14-base pair (bp) long insertion (ins)/deletion (del) polymorphism in exon 8 in the 3'-untranslated region of the human leukocyte antigen (HLA)-G gene is suggested to affect transcription of the gene. Carriage of the G14bp ins is associated with low levels of soluble HLA-G and increases the risk of recurrent miscarriage (RM). Due to existence of strong linkage disequilibrium (LD) in the HLA region, the primary susceptibility genes for RM in the HLA-G region have not yet been identified. HLA-A, -B, -DRB1, and -G14bp polymorphisms were investigated in 29 Caucasian families with two or more siblings suffering unexplained RM. Strong positive LD was detected between the G14bp ins and HLA-A*01, -A*11, -A*31, -B*08, and DRB1*03, whereas strong negative LD was found between G14bp ins and HLA-A*02, -A*03, and -A*24. The frequency of haplotypes with HLA-G14bp ins inherited from the mother was significantly increased in probands with RM (p = 0.05). The increased compatibility between probands and their mothers for maternal G14 ins positive haplotypes suggests that maternal-fetal compatibility for chromosomal segments adjacent to HLA-G locus is a risk factor for female offspring to experience RM in their later reproductive life.
KW - Abortion, Habitual
KW - Female
KW - Genetic Predisposition to Disease
KW - HLA Antigens
KW - HLA-A Antigens
KW - HLA-B Antigens
KW - HLA-DR Antigens
KW - HLA-DRB1 Chains
KW - HLA-G Antigens
KW - Haplotypes
KW - Histocompatibility Antigens Class I
KW - Humans
KW - Linkage Disequilibrium
KW - Pedigree
KW - Pregnancy
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1016/j.humimm.2010.02.001
DO - 10.1016/j.humimm.2010.02.001
M3 - Journal article
C2 - 20149831
VL - 71
SP - 482
EP - 488
JO - Human Immunology
JF - Human Immunology
SN - 0198-8859
IS - 5
ER -
ID: 188691351