Stimulation of the N-methyl-D-aspartate receptor has a trophic effect on differentiating cerebellar granule cells.

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Stimulation of the N-methyl-D-aspartate receptor has a trophic effect on differentiating cerebellar granule cells. / Balázs, R; Hack, N; Jørgensen, Ole Steen.

In: Neuroscience Letters, Vol. 87, No. 1-2, 1988, p. 80-6.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Balázs, R, Hack, N & Jørgensen, OS 1988, 'Stimulation of the N-methyl-D-aspartate receptor has a trophic effect on differentiating cerebellar granule cells.', Neuroscience Letters, vol. 87, no. 1-2, pp. 80-6.

APA

Balázs, R., Hack, N., & Jørgensen, O. S. (1988). Stimulation of the N-methyl-D-aspartate receptor has a trophic effect on differentiating cerebellar granule cells. Neuroscience Letters, 87(1-2), 80-6.

Vancouver

Balázs R, Hack N, Jørgensen OS. Stimulation of the N-methyl-D-aspartate receptor has a trophic effect on differentiating cerebellar granule cells. Neuroscience Letters. 1988;87(1-2):80-6.

Author

Balázs, R ; Hack, N ; Jørgensen, Ole Steen. / Stimulation of the N-methyl-D-aspartate receptor has a trophic effect on differentiating cerebellar granule cells. In: Neuroscience Letters. 1988 ; Vol. 87, No. 1-2. pp. 80-6.

Bibtex

@article{84c141807da011dd81b0000ea68e967b,
title = "Stimulation of the N-methyl-D-aspartate receptor has a trophic effect on differentiating cerebellar granule cells.",
abstract = "N-methyl-D-aspartate (NMDA) supplementation of cerebellar cultures enriched in granule neurones (about 90%) prevented the extensive cell loss which occurs when cultivation takes place, in serum containing media, in the presence of 'low' K+ (5-15 mM). Estimation of tetanus toxin receptors and N-CAM contents indicated that NMDA rescued primarily nerve cells. The influence of NMDA in promoting cell survival was blocked by the receptor antagonist, 2-amino-5-phosphonovalerate. The effect depended both on the concentration of NMDA and on the degree of depolarization of cells, the affinity in the presence of 15 mM K+ being similar to that of NMDA receptor binding. The results attest a new role for excitatory amino acid transmitters by showing that they can exert a stage-dependent trophic action on developing nerve cells.",
author = "R Bal{\'a}zs and N Hack and J{\o}rgensen, {Ole Steen}",
note = "Keywords: Animals; Antigens, Surface; Aspartic Acid; Cell Adhesion Molecules; Cell Count; Cell Differentiation; Cell Survival; Cells, Cultured; Cerebellum; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tetanus Toxin",
year = "1988",
language = "English",
volume = "87",
pages = "80--6",
journal = "Neuroscience letters. Supplement",
issn = "0167-6253",
publisher = "Elsevier Ireland Ltd",
number = "1-2",

}

RIS

TY - JOUR

T1 - Stimulation of the N-methyl-D-aspartate receptor has a trophic effect on differentiating cerebellar granule cells.

AU - Balázs, R

AU - Hack, N

AU - Jørgensen, Ole Steen

N1 - Keywords: Animals; Antigens, Surface; Aspartic Acid; Cell Adhesion Molecules; Cell Count; Cell Differentiation; Cell Survival; Cells, Cultured; Cerebellum; N-Methylaspartate; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Tetanus Toxin

PY - 1988

Y1 - 1988

N2 - N-methyl-D-aspartate (NMDA) supplementation of cerebellar cultures enriched in granule neurones (about 90%) prevented the extensive cell loss which occurs when cultivation takes place, in serum containing media, in the presence of 'low' K+ (5-15 mM). Estimation of tetanus toxin receptors and N-CAM contents indicated that NMDA rescued primarily nerve cells. The influence of NMDA in promoting cell survival was blocked by the receptor antagonist, 2-amino-5-phosphonovalerate. The effect depended both on the concentration of NMDA and on the degree of depolarization of cells, the affinity in the presence of 15 mM K+ being similar to that of NMDA receptor binding. The results attest a new role for excitatory amino acid transmitters by showing that they can exert a stage-dependent trophic action on developing nerve cells.

AB - N-methyl-D-aspartate (NMDA) supplementation of cerebellar cultures enriched in granule neurones (about 90%) prevented the extensive cell loss which occurs when cultivation takes place, in serum containing media, in the presence of 'low' K+ (5-15 mM). Estimation of tetanus toxin receptors and N-CAM contents indicated that NMDA rescued primarily nerve cells. The influence of NMDA in promoting cell survival was blocked by the receptor antagonist, 2-amino-5-phosphonovalerate. The effect depended both on the concentration of NMDA and on the degree of depolarization of cells, the affinity in the presence of 15 mM K+ being similar to that of NMDA receptor binding. The results attest a new role for excitatory amino acid transmitters by showing that they can exert a stage-dependent trophic action on developing nerve cells.

M3 - Journal article

C2 - 2837687

VL - 87

SP - 80

EP - 86

JO - Neuroscience letters. Supplement

JF - Neuroscience letters. Supplement

SN - 0167-6253

IS - 1-2

ER -

ID: 5941375