Socioeconomic and humanistic burden of illness of excessive daytime sleepiness severity associated with obstructive sleep apnoea in the European Union 5
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Socioeconomic and humanistic burden of illness of excessive daytime sleepiness severity associated with obstructive sleep apnoea in the European Union 5. / Jennum, Poul; Coaquira Castro, Jean Pierre; Mettam, Sam; Kharkevitch, Tatiana; Cambron-Mellott, M. Janelle.
In: Sleep Medicine, Vol. 84, 2021, p. 46-55.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Socioeconomic and humanistic burden of illness of excessive daytime sleepiness severity associated with obstructive sleep apnoea in the European Union 5
AU - Jennum, Poul
AU - Coaquira Castro, Jean Pierre
AU - Mettam, Sam
AU - Kharkevitch, Tatiana
AU - Cambron-Mellott, M. Janelle
N1 - Publisher Copyright: © 2021 The Authors
PY - 2021
Y1 - 2021
N2 - Objective/Background: Evaluate the impact of excessive daytime sleepiness (EDS) severity on burden of illness among adults with obstructive sleep apnoea (OSA) in European Union 5 (EU5) countries (France, Germany, Italy, Spain, United Kingdom). Patients/Methods: This retrospective observational study used data from the 2017 EU5 National Health and Wellness Survey, a self-administered, internet-based, non-screening survey. Respondents who self-reported both having experienced OSA in the last 12 months and having had their OSA diagnosed by a physician were considered to have OSA. Respondents completed the Epworth Sleepiness Scale (ESS) and were consequently categorised into 4 groups: OSA-with-EDS (ESS >10) subdivided by EDS severity (mild [ESS = 11–12], moderate [ESS = 13–15], severe [ESS = 16–24]), and OSA-without-EDS (ESS ≤10). Bivariate and multivariable analyses examined group differences in health-related quality of life (HRQoL), work productivity and activity impairment, and health care utilisation. Results: The analysis included 2008 respondents with OSA: n = 661 (32.9%) with EDS (29.5% mild, 34.5% moderate, 36.0% severe) and n = 1347 without EDS. Compared with the OSA-without-EDS group, the OSA-with-EDS subgroups generally had higher rates of obesity, depression, and other reported comorbidities. Greater severity of EDS was associated with worse self-reported HRQoL (all domains, P < 0.001) and work productivity and activity impairment (absenteeism, P = 0.031; presenteeism, overall work impairment, and non–work activity impairment, P < 0.001), as well as increased numbers of health care provider visits (P < 0.001). Conclusions: Compared to patients with OSA but without EDS, those with EDS had substantially higher socioeconomic and humanistic burden of disease, which was more profound among those reporting greater EDS.
AB - Objective/Background: Evaluate the impact of excessive daytime sleepiness (EDS) severity on burden of illness among adults with obstructive sleep apnoea (OSA) in European Union 5 (EU5) countries (France, Germany, Italy, Spain, United Kingdom). Patients/Methods: This retrospective observational study used data from the 2017 EU5 National Health and Wellness Survey, a self-administered, internet-based, non-screening survey. Respondents who self-reported both having experienced OSA in the last 12 months and having had their OSA diagnosed by a physician were considered to have OSA. Respondents completed the Epworth Sleepiness Scale (ESS) and were consequently categorised into 4 groups: OSA-with-EDS (ESS >10) subdivided by EDS severity (mild [ESS = 11–12], moderate [ESS = 13–15], severe [ESS = 16–24]), and OSA-without-EDS (ESS ≤10). Bivariate and multivariable analyses examined group differences in health-related quality of life (HRQoL), work productivity and activity impairment, and health care utilisation. Results: The analysis included 2008 respondents with OSA: n = 661 (32.9%) with EDS (29.5% mild, 34.5% moderate, 36.0% severe) and n = 1347 without EDS. Compared with the OSA-without-EDS group, the OSA-with-EDS subgroups generally had higher rates of obesity, depression, and other reported comorbidities. Greater severity of EDS was associated with worse self-reported HRQoL (all domains, P < 0.001) and work productivity and activity impairment (absenteeism, P = 0.031; presenteeism, overall work impairment, and non–work activity impairment, P < 0.001), as well as increased numbers of health care provider visits (P < 0.001). Conclusions: Compared to patients with OSA but without EDS, those with EDS had substantially higher socioeconomic and humanistic burden of disease, which was more profound among those reporting greater EDS.
KW - Burden of illness
KW - Excessive daytime sleepiness
KW - Health care resource utilisation
KW - Obstructive sleep apnoea
KW - Quality of life
KW - Work productivity
UR - http://www.scopus.com/inward/record.url?scp=85107263447&partnerID=8YFLogxK
U2 - 10.1016/j.sleep.2021.05.010
DO - 10.1016/j.sleep.2021.05.010
M3 - Journal article
C2 - 34102429
AN - SCOPUS:85107263447
VL - 84
SP - 46
EP - 55
JO - Sleep Medicine
JF - Sleep Medicine
SN - 1389-9457
ER -
ID: 305026116