TY - JOUR

T1 - Social responsiveness in families with parental schizophrenia or bipolar disorder—The Danish High Risk and Resilience Study

AU - Veddum, Lotte

AU - Gregersen, Maja

AU - Andreassen, Anna Krogh

AU - Knudsen, Christina Bruun

AU - Brandt, Julie Marie

AU - Krantz, Mette Falkenberg

AU - Søndergaard, Anne

AU - Burton, Birgitte Klee

AU - Jepsen, Jens Richardt Møllegaard

AU - Hemager, Nicoline

AU - Thorup, Anne Amalie Elgaard

AU - Nordentoft, Merete

AU - Mors, Ole

AU - Bliksted, Vibeke

AU - Greve, Aja Neergaard

N1 - Publisher Copyright: © 2023 The Author(s)

PY - 2023

Y1 - 2023

N2 - Schizophrenia and bipolar disorder are highly heritable severe mental disorders associated with social impairments. Moreover, partners to individuals with one of these disorders display poorer functioning and more psychopathology, but their social skills and the transgenerational transmission remains uninvestigated. Therefore, we aimed to examine social responsiveness in families with parental schizophrenia or bipolar disorder. The cohort consists of 11-year-old children with at least one parent with schizophrenia (n = 179) or bipolar disorder (n = 105) and population-based controls (PBC, n = 181). Children and parents were assessed with The Social Responsiveness Scale, Second Edition. Duration of time each parent and child have lived together was ascertained through interviews. Parents with schizophrenia and parents with bipolar disorder exhibited poorer social responsiveness compared with PBC parents. Parents with schizophrenia displayed poorer social responsiveness compared with parents with bipolar disorder. Schizophrenia co-parents exhibited poorer social responsiveness compared with bipolar co-parents and PBC co-parents. We found significant positive associations between parents’ and children's social responsiveness, with no interaction effect of duration of time living together. Considering that social impairments are suggested as a vulnerability marker, this knowledge calls for increased attention towards vulnerable families, particularly those where both parents have social impairments.

AB - Schizophrenia and bipolar disorder are highly heritable severe mental disorders associated with social impairments. Moreover, partners to individuals with one of these disorders display poorer functioning and more psychopathology, but their social skills and the transgenerational transmission remains uninvestigated. Therefore, we aimed to examine social responsiveness in families with parental schizophrenia or bipolar disorder. The cohort consists of 11-year-old children with at least one parent with schizophrenia (n = 179) or bipolar disorder (n = 105) and population-based controls (PBC, n = 181). Children and parents were assessed with The Social Responsiveness Scale, Second Edition. Duration of time each parent and child have lived together was ascertained through interviews. Parents with schizophrenia and parents with bipolar disorder exhibited poorer social responsiveness compared with PBC parents. Parents with schizophrenia displayed poorer social responsiveness compared with parents with bipolar disorder. Schizophrenia co-parents exhibited poorer social responsiveness compared with bipolar co-parents and PBC co-parents. We found significant positive associations between parents’ and children's social responsiveness, with no interaction effect of duration of time living together. Considering that social impairments are suggested as a vulnerability marker, this knowledge calls for increased attention towards vulnerable families, particularly those where both parents have social impairments.

KW - Familial high-risk

KW - Nonrandom mating

KW - Parental mental illness

KW - Social skills

KW - Transgenerational transmission

U2 - 10.1016/j.psychres.2023.115140

DO - 10.1016/j.psychres.2023.115140

M3 - Journal article

C2 - 36898170

AN - SCOPUS:85149659101

VL - 323

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

M1 - 115140

ER -