Sleep Disorders
Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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Sleep Disorders. / Kornum, Birgitte Rahbek; Mignot, Emmanuel.
Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders. ed. / Michael J. Zigmond; Lewis P. Rowland; Joseph T. Coyle. London : Elsevier Science Inc., 2015. p. 585-611.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review
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TY - CHAP
T1 - Sleep Disorders
AU - Kornum, Birgitte Rahbek
AU - Mignot, Emmanuel
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Mammalian sleep has evolved under the influence of the day-night cycle and in response to reproductive needs, food seeking, and predator avoidance, resulting in circadian (predictive) and homeostatic (reactive) regulation. A molecular clock characterized by transcription/translation feedback loops mediates circadian regulation of sleep. Misalignment with the rhythm of the sun results in circadian disorders and jet lag. The molecular basis of homeostatic sleep regulation is mostly unknown. A network of mutually inhibitory brain nuclei regulates sleep states and sleep-wake transitions. Abnormalities in these networks create sleep disorders, including rapid eye movement sleep behavior disorder, sleep walking, and narcolepsy. Physiological changes associated with sleep can be imbalanced, resulting in excess movements such as periodic leg movements during sleep or abnormal breathing in obstructive sleep apneas. As every organ in the body is affected by sleep directly or indirectly, sleep and sleep-associated disorders are frequent and only now starting to be understood.
AB - Mammalian sleep has evolved under the influence of the day-night cycle and in response to reproductive needs, food seeking, and predator avoidance, resulting in circadian (predictive) and homeostatic (reactive) regulation. A molecular clock characterized by transcription/translation feedback loops mediates circadian regulation of sleep. Misalignment with the rhythm of the sun results in circadian disorders and jet lag. The molecular basis of homeostatic sleep regulation is mostly unknown. A network of mutually inhibitory brain nuclei regulates sleep states and sleep-wake transitions. Abnormalities in these networks create sleep disorders, including rapid eye movement sleep behavior disorder, sleep walking, and narcolepsy. Physiological changes associated with sleep can be imbalanced, resulting in excess movements such as periodic leg movements during sleep or abnormal breathing in obstructive sleep apneas. As every organ in the body is affected by sleep directly or indirectly, sleep and sleep-associated disorders are frequent and only now starting to be understood.
KW - Circadian rhythm
KW - Narcolepsy
KW - Rapid eye movement behavior disorder
KW - Restless legs syndrome
KW - Sleep
KW - Sleep homeostasis
U2 - 10.1016/B978-0-12-398270-4.00036-7
DO - 10.1016/B978-0-12-398270-4.00036-7
M3 - Book chapter
SN - 9780123982704
SP - 585
EP - 611
BT - Neurobiology of Brain Disorders
A2 - Zigmond, Michael J.
A2 - Rowland, Lewis P.
A2 - Coyle, Joseph T.
PB - Elsevier Science Inc.
CY - London
ER -
ID: 236510274