Skeletal (stromal) stem cells: An update on intracellular signaling pathways controlling osteoblast differentiation
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Skeletal (stromal) stem cells : An update on intracellular signaling pathways controlling osteoblast differentiation. / Abdallah, Basem M; Kermani, Abbas Jafari; Zaher, Walid; Qiu, Weimin; Kassem, Moustapha.
In: Bone, Vol. 70, 2015, p. 28-36.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Skeletal (stromal) stem cells
T2 - An update on intracellular signaling pathways controlling osteoblast differentiation
AU - Abdallah, Basem M
AU - Kermani, Abbas Jafari
AU - Zaher, Walid
AU - Qiu, Weimin
AU - Kassem, Moustapha
N1 - Copyright © 2014 Elsevier Inc. All rights reserved.
PY - 2015
Y1 - 2015
N2 - Skeletal (marrow stromal) stem cells (BMSCs) are a group of multipotent cells that reside in the bone marrow stroma and can differentiate into osteoblasts, chondrocytes and adipocytes. Studying signaling pathways that regulate BMSC differentiation into osteoblastic cells is a strategy for identifying druggable targets for enhancing bone formation. This review will discuss the functions and the molecular mechanisms of action on osteoblast differentiation and bone formation; of a number of recently identified regulatory molecules: the non-canonical Notch signaling molecule Delta-like 1/preadipocyte factor 1 (Dlk1/Pref-1), the Wnt co-receptor Lrp5 and intracellular kinases. This article is part of a Special Issue entitled: Stem Cells and Bone.
AB - Skeletal (marrow stromal) stem cells (BMSCs) are a group of multipotent cells that reside in the bone marrow stroma and can differentiate into osteoblasts, chondrocytes and adipocytes. Studying signaling pathways that regulate BMSC differentiation into osteoblastic cells is a strategy for identifying druggable targets for enhancing bone formation. This review will discuss the functions and the molecular mechanisms of action on osteoblast differentiation and bone formation; of a number of recently identified regulatory molecules: the non-canonical Notch signaling molecule Delta-like 1/preadipocyte factor 1 (Dlk1/Pref-1), the Wnt co-receptor Lrp5 and intracellular kinases. This article is part of a Special Issue entitled: Stem Cells and Bone.
U2 - 10.1016/j.bone.2014.07.028
DO - 10.1016/j.bone.2014.07.028
M3 - Journal article
C2 - 25138551
VL - 70
SP - 28
EP - 36
JO - Bone
JF - Bone
SN - 8756-3282
ER -
ID: 125952700