Single-nucleus transcriptomics identifies separate classes of UCP1 and futile cycle adipocytes
Research output: Contribution to journal › Journal article › Research › peer-review
Adipose tissue can recruit catabolic adipocytes that utilize chemical energy to dissipate heat. This process occurs either by uncoupled respiration through uncoupling protein 1 (UCP1) or by utilizing ATP-dependent futile cycles (FCs). However, it remains unclear how these pathways coexist since both processes rely on the mitochondrial membrane potential. Utilizing single-nucleus RNA sequencing to deconvolute the heterogeneity of subcutaneous adipose tissue in mice and humans, we identify at least 2 distinct subpopulations of beige adipocytes: FC-adipocytes and UCP1-beige adipocytes. Importantly, we demonstrate that the FC-adipocyte subpopulation is highly metabolically active and utilizes FCs to dissipate energy, thus contributing to thermogenesis independent of Ucp1. Furthermore, FC-adipocytes are important drivers of systemic energy homeostasis and linked to glucose metabolism and obesity resistance in humans. Taken together, our findings identify a noncanonical thermogenic adipocyte subpopulation, which could be an important regulator of energy homeostasis in mammals.
Original language | English |
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Journal | Cell Metabolism |
ISSN | 1550-4131 |
DOIs | |
Publication status | E-pub ahead of print - 2024 |
Bibliographical note
Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.
ID: 400308101