Simple Mucin-Type Carbohydrates in Normal and Malignant Human Endometrium
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Simple Mucin-Type Carbohydrates in Normal and Malignant Human Endometrium. / Ravn, Vibeke; Mandel, Ulla; Svenstrup, Birgit; Dabelsteen, Erik.
In: International Journal of Gynecological Pathology, Vol. 14, No. 2, 1995, p. 158-66.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Simple Mucin-Type Carbohydrates in Normal and Malignant Human Endometrium
AU - Ravn, Vibeke
AU - Mandel, Ulla
AU - Svenstrup, Birgit
AU - Dabelsteen, Erik
PY - 1995
Y1 - 1995
N2 - The simple mucin-type carbohydrate antigens, Tn, sialosyl-Tn, and T, are tumor-associated antigens of adenocarcinomas. We evaluated by immunohistochemistry the expression of Tn, sialosyl-Tn (s-Tn), T, and sialosyl-T (s-T) antigens in normal nonsecretory, early gestational, and malignant human endometrium in relation to genetic (ABO/Lewis blood-type) and hormonal factors. The blood group status had no influence on staining. Tn and s-Tn antigens were infrequently demonstrated in normal nonsecretory endometria but showed an increased expression in adenomatous hyperplasias and endometrial carcinomas, which was unrelated to estradiol (E2) levels, grade, and stage. The T disaccharide was demonstrated infrequently in both normal and malignant endometrium. Staining for T antigen showed an inverse correlation to serum E2 levels. In contrast, s-T antigen showed a pronounced but varied expression in normal and malignant endometrium, and the expression of s-T antigen was positively correlated with E2 levels in serum. Our findings suggest a hormonal influence on expression of simple mucin-type carbohydrates in human endometrium. However, the accumulation of Tn and s-Tn antigens in malignant endometrial cells seem to be unrelated to both genetic and hormonal factors. Because s-Tn is also expressed by secretory endometria, only Tn antigen can be considered a "tumor-associated" antigen of endometrial tissue.
AB - The simple mucin-type carbohydrate antigens, Tn, sialosyl-Tn, and T, are tumor-associated antigens of adenocarcinomas. We evaluated by immunohistochemistry the expression of Tn, sialosyl-Tn (s-Tn), T, and sialosyl-T (s-T) antigens in normal nonsecretory, early gestational, and malignant human endometrium in relation to genetic (ABO/Lewis blood-type) and hormonal factors. The blood group status had no influence on staining. Tn and s-Tn antigens were infrequently demonstrated in normal nonsecretory endometria but showed an increased expression in adenomatous hyperplasias and endometrial carcinomas, which was unrelated to estradiol (E2) levels, grade, and stage. The T disaccharide was demonstrated infrequently in both normal and malignant endometrium. Staining for T antigen showed an inverse correlation to serum E2 levels. In contrast, s-T antigen showed a pronounced but varied expression in normal and malignant endometrium, and the expression of s-T antigen was positively correlated with E2 levels in serum. Our findings suggest a hormonal influence on expression of simple mucin-type carbohydrates in human endometrium. However, the accumulation of Tn and s-Tn antigens in malignant endometrial cells seem to be unrelated to both genetic and hormonal factors. Because s-Tn is also expressed by secretory endometria, only Tn antigen can be considered a "tumor-associated" antigen of endometrial tissue.
KW - Adenocarcinoma
KW - Antibodies, Monoclonal
KW - Antigens, Tumor-Associated, Carbohydrate
KW - Endometrial Hyperplasia
KW - Endometrial Neoplasms
KW - Endometrium
KW - Female
KW - Humans
KW - Immunohistochemistry
U2 - 10.1097/00004347-199504000-00010
DO - 10.1097/00004347-199504000-00010
M3 - Journal article
C2 - 8601528
VL - 14
SP - 158
EP - 166
JO - International Journal of Gynecological Pathology
JF - International Journal of Gynecological Pathology
SN - 0277-1691
IS - 2
ER -
ID: 119594697