Simple mucins (T, sialosyl-T, Tn and sialosyl-Tn) are not diagnostic for malignant breast lesions
Research output: Contribution to journal › Journal article › Research › peer-review
Immunohistochemical study of the distribution of carbohydrate core-structures on O-linked glycoproteins (T, sialosyl-T, Tn and sialosyl-Tn) was performed using specific monoclonal antibodies on 148 primary breast lesions, including 10 normal breast tissues, 16 benign lesions and 122 invasive carcinomas (79 localized and 43 metastatic lesions). T antigen, not observed in normal breast tissue, was present in 31% of the benign lesions and in some cases of morphologically normal epithelium adjacent to tumor cells, compatible with altered glycosylation being an early event. Sialosyl-T (s-T) antigen was present in all cases of normal epithelium and in 81% of the benign lesions. Both Tn and sialosyl-Tn (s-Tn) antigen were present in normal breast lesions. Both Tn and sialosyl-Tn (s-Tn) antigen were present in normal breast tissue (30%) and benign lesions (31% and 19%). In the malignant lesions, 20% were positive for T antigen, 82% for s-T antigen, 66% for Tn antigen and 22% for s-Tn antigen. The staining pattern was nearly identical for carcinomas with and without lymph node metastases. In conclusion, immunostaining for simple mucins does not permit a clear distinction between benign and malignant breast lesions.
Original language | English |
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Journal | Anticancer Research |
Volume | 14 |
Issue number | 2B |
Pages (from-to) | 609-15 |
Number of pages | 7 |
ISSN | 0250-7005 |
Publication status | Published - 1 Mar 1994 |
- Antibodies, Monoclonal, Antigens, Tumor-Associated, Carbohydrate, Antigens, Viral, Tumor, Biological Markers, Breast, Breast Neoplasms, Carbohydrate Sequence, Carbohydrates, Carcinoma, Ductal, Breast, Epithelial Cells, Epithelium, Epitopes, Female, Humans, Immunohistochemistry, Molecular Sequence Data, Mucins, Neoplasm Invasiveness, Neoplasm Metastasis, Oligosaccharides, Tumor Markers, Biological
Research areas
ID: 119595406