Similar weight-adjusted insulin secretion and insulin sensitivity in short-duration late autoimmune diabetes of adulthood (LADA) and Type 2 diabetes: Action LADA 8
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Similar weight-adjusted insulin secretion and insulin sensitivity in short-duration late autoimmune diabetes of adulthood (LADA) and Type 2 diabetes : Action LADA 8. / Juhl, C B; Bradley, U; Holst, Jens Juul; Leslie, R D; Yderstraede, K B; Hunter, S; Action LADA Consortium.
In: Diabetic Medicine, Vol. 31, No. 8, 15.03.2014, p. 941-945.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Similar weight-adjusted insulin secretion and insulin sensitivity in short-duration late autoimmune diabetes of adulthood (LADA) and Type 2 diabetes
T2 - Action LADA 8
AU - Juhl, C B
AU - Bradley, U
AU - Holst, Jens Juul
AU - Leslie, R D
AU - Yderstraede, K B
AU - Hunter, S
AU - Action LADA Consortium
N1 - © 2014 The Authors. Diabetic Medicine © 2014 Diabetes UK.
PY - 2014/3/15
Y1 - 2014/3/15
N2 - AIMS: To explore insulin sensitivity and insulin secretion in people with latent autoimmune diabetes in adulthood (LADA) compared with that in people with Type 2 diabetes.METHODS: A total of 12 people with LADA, defined as glutamic acid decarboxylase (GAD) antibody positivity and > 1 year of insulin independency (group A) were age-matched pairwise to people with Type 2 diabetes (group B) and to six people with Type 2 diabetes of similar age and BMI (group C). β-cell function (first-phase insulin secretion and assessment of insulin pulsatility), insulin sensitivity (hyperinsulinemic-euglycemic clamp) and metabolic response during a mixed meal were studied.RESULTS: Both first-phase insulin secretion and insulin release during the meal were greater (P = 0.05 and P = 0.009, respectively) in Type 2 diabetes as compared with LADA; these differences were lost on adjustment for BMI (group C) and could be explained by BMI alone in a multivariate analysis. Neither insulin pulsatility, incretin secretion nor insulin sensitivity differed among the groups.CONCLUSIONS: We found no evidence that LADA and Type 2 diabetes were distinct disease entities beyond the differences explained by BMI.
AB - AIMS: To explore insulin sensitivity and insulin secretion in people with latent autoimmune diabetes in adulthood (LADA) compared with that in people with Type 2 diabetes.METHODS: A total of 12 people with LADA, defined as glutamic acid decarboxylase (GAD) antibody positivity and > 1 year of insulin independency (group A) were age-matched pairwise to people with Type 2 diabetes (group B) and to six people with Type 2 diabetes of similar age and BMI (group C). β-cell function (first-phase insulin secretion and assessment of insulin pulsatility), insulin sensitivity (hyperinsulinemic-euglycemic clamp) and metabolic response during a mixed meal were studied.RESULTS: Both first-phase insulin secretion and insulin release during the meal were greater (P = 0.05 and P = 0.009, respectively) in Type 2 diabetes as compared with LADA; these differences were lost on adjustment for BMI (group C) and could be explained by BMI alone in a multivariate analysis. Neither insulin pulsatility, incretin secretion nor insulin sensitivity differed among the groups.CONCLUSIONS: We found no evidence that LADA and Type 2 diabetes were distinct disease entities beyond the differences explained by BMI.
U2 - 10.1111/dme.12434
DO - 10.1111/dme.12434
M3 - Journal article
C2 - 24628669
VL - 31
SP - 941
EP - 945
JO - Diabetic Medicine
JF - Diabetic Medicine
SN - 0742-3071
IS - 8
ER -
ID: 117854020