Short-term study of the uptake of PrPSc by the Peyer’s patches in hamsters after oral exposure to scrapie

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Short-term study of the uptake of PrPSc by the Peyer’s patches in hamsters after oral exposure to scrapie. / Bergström, Ann-Louise; Jensen, Tim Kåre; Heegaard, Peter; Hvass, Henriette Cordes; Hansen, V. B.; Laursen, H.; Lind, Peter.

In: Journal of Comparative Pathology, Vol. 134, No. 2-3, 2006, p. 126-133.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bergström, A-L, Jensen, TK, Heegaard, P, Hvass, HC, Hansen, VB, Laursen, H & Lind, P 2006, 'Short-term study of the uptake of PrPSc by the Peyer’s patches in hamsters after oral exposure to scrapie', Journal of Comparative Pathology, vol. 134, no. 2-3, pp. 126-133. https://doi.org/10.1016/j.jcpa.2005.08.002

APA

Bergström, A-L., Jensen, T. K., Heegaard, P., Hvass, H. C., Hansen, V. B., Laursen, H., & Lind, P. (2006). Short-term study of the uptake of PrPSc by the Peyer’s patches in hamsters after oral exposure to scrapie. Journal of Comparative Pathology, 134(2-3), 126-133. https://doi.org/10.1016/j.jcpa.2005.08.002

Vancouver

Bergström A-L, Jensen TK, Heegaard P, Hvass HC, Hansen VB, Laursen H et al. Short-term study of the uptake of PrPSc by the Peyer’s patches in hamsters after oral exposure to scrapie. Journal of Comparative Pathology. 2006;134(2-3):126-133. https://doi.org/10.1016/j.jcpa.2005.08.002

Author

Bergström, Ann-Louise ; Jensen, Tim Kåre ; Heegaard, Peter ; Hvass, Henriette Cordes ; Hansen, V. B. ; Laursen, H. ; Lind, Peter. / Short-term study of the uptake of PrPSc by the Peyer’s patches in hamsters after oral exposure to scrapie. In: Journal of Comparative Pathology. 2006 ; Vol. 134, No. 2-3. pp. 126-133.

Bibtex

@article{bae35a3624a14195bc0210fe6ea15027,
title = "Short-term study of the uptake of PrPSc by the Peyer{\textquoteright}s patches in hamsters after oral exposure to scrapie",
abstract = "The disease-associated prion protein (PrPSc) has been detected in the ileal Peyer's patches of lambs as early as one week after oral exposure to scrapie. In hamsters, the earliest reported time of PrPSc detection in the Peyer's patches after oral exposure to scrapie is 69 days post-infection. To evaluate the acute uptake of inoculum and to investigate whether the Peyer's patches constitute the primary site of entry for scrapie after oral exposure, hamsters were each exposed orally to 1 ml of a 10% brain homogenate from hamsters in the terminal stage of infection with the 263 K strain of the scrapie agent. PrPSc was demonstrated in the Peyer's patches only a few days after exposure, i.e., much earlier than previously reported. This study Supports the view that the Peyer's patches constitute at least one of the primary entry sites of PrPSc after oral exposure to scrapie.",
author = "Ann-Louise Bergstr{\"o}m and Jensen, {Tim K{\aa}re} and Peter Heegaard and Hvass, {Henriette Cordes} and Hansen, {V. B.} and H. Laursen and Peter Lind",
year = "2006",
doi = "10.1016/j.jcpa.2005.08.002",
language = "English",
volume = "134",
pages = "126--133",
journal = "Journal of Comparative Pathology",
issn = "0021-9975",
publisher = "Elsevier",
number = "2-3",

}

RIS

TY - JOUR

T1 - Short-term study of the uptake of PrPSc by the Peyer’s patches in hamsters after oral exposure to scrapie

AU - Bergström, Ann-Louise

AU - Jensen, Tim Kåre

AU - Heegaard, Peter

AU - Hvass, Henriette Cordes

AU - Hansen, V. B.

AU - Laursen, H.

AU - Lind, Peter

PY - 2006

Y1 - 2006

N2 - The disease-associated prion protein (PrPSc) has been detected in the ileal Peyer's patches of lambs as early as one week after oral exposure to scrapie. In hamsters, the earliest reported time of PrPSc detection in the Peyer's patches after oral exposure to scrapie is 69 days post-infection. To evaluate the acute uptake of inoculum and to investigate whether the Peyer's patches constitute the primary site of entry for scrapie after oral exposure, hamsters were each exposed orally to 1 ml of a 10% brain homogenate from hamsters in the terminal stage of infection with the 263 K strain of the scrapie agent. PrPSc was demonstrated in the Peyer's patches only a few days after exposure, i.e., much earlier than previously reported. This study Supports the view that the Peyer's patches constitute at least one of the primary entry sites of PrPSc after oral exposure to scrapie.

AB - The disease-associated prion protein (PrPSc) has been detected in the ileal Peyer's patches of lambs as early as one week after oral exposure to scrapie. In hamsters, the earliest reported time of PrPSc detection in the Peyer's patches after oral exposure to scrapie is 69 days post-infection. To evaluate the acute uptake of inoculum and to investigate whether the Peyer's patches constitute the primary site of entry for scrapie after oral exposure, hamsters were each exposed orally to 1 ml of a 10% brain homogenate from hamsters in the terminal stage of infection with the 263 K strain of the scrapie agent. PrPSc was demonstrated in the Peyer's patches only a few days after exposure, i.e., much earlier than previously reported. This study Supports the view that the Peyer's patches constitute at least one of the primary entry sites of PrPSc after oral exposure to scrapie.

U2 - 10.1016/j.jcpa.2005.08.002

DO - 10.1016/j.jcpa.2005.08.002

M3 - Journal article

VL - 134

SP - 126

EP - 133

JO - Journal of Comparative Pathology

JF - Journal of Comparative Pathology

SN - 0021-9975

IS - 2-3

ER -

ID: 339890695