Sex differences in coeliac disease risk: a Swedish sibling design study
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Sex differences in coeliac disease risk : a Swedish sibling design study. / Clinical Sciences, Malmö, Lund University, Department; Agardh, Daniel; Merlo, Juan.
In: Rendiconti di Gastro-Enterologia, Vol. 44, No. 11, 11.2012, p. 909-13.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Sex differences in coeliac disease risk
T2 - a Swedish sibling design study
AU - Clinical Sciences, Malmö, Lund University, Department
AU - Agardh, Daniel
AU - Merlo, Juan
N1 - Copyright © 2012 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
PY - 2012/11
Y1 - 2012/11
N2 - BACKGROUND: For unknown reasons girls are at an increased risk of coeliac disease compared to boys. However, the observed association might be confounded, since maternal coeliac disease is associated with both an increased risk of the disease in first-degree relatives as well as an increased ratio of girls to boys in offspring.AIMS: We investigate the effect of sex on the risk of coeliac disease before the age of two years using sibling design.METHODS: We identified all singleton children (n=792,401) born between 1987 and 1993 in Sweden using the Swedish Medical Birth Registry. Coeliac disease cases (2264) were identified using the Swedish National Inpatient Registry. We applied both conventional population-based Cox regression models and sibling designs modelling the association in sex discordant siblings.RESULTS: We observed a conclusively increased risk of coeliac disease in girls compared to boys, using both sibling design (hazard ratio 1.67, 95% confidence interval 1.44-1.93) and conventional Cox regression analysis (hazard ratio 1.75, 95% confidence interval 1.61-1.91) that could not be explained by perinatal factors previously associated with the disease.CONCLUSIONS: We confirm that female sex is causally associated with childhood coeliac disease, but the reasons remains unknown.
AB - BACKGROUND: For unknown reasons girls are at an increased risk of coeliac disease compared to boys. However, the observed association might be confounded, since maternal coeliac disease is associated with both an increased risk of the disease in first-degree relatives as well as an increased ratio of girls to boys in offspring.AIMS: We investigate the effect of sex on the risk of coeliac disease before the age of two years using sibling design.METHODS: We identified all singleton children (n=792,401) born between 1987 and 1993 in Sweden using the Swedish Medical Birth Registry. Coeliac disease cases (2264) were identified using the Swedish National Inpatient Registry. We applied both conventional population-based Cox regression models and sibling designs modelling the association in sex discordant siblings.RESULTS: We observed a conclusively increased risk of coeliac disease in girls compared to boys, using both sibling design (hazard ratio 1.67, 95% confidence interval 1.44-1.93) and conventional Cox regression analysis (hazard ratio 1.75, 95% confidence interval 1.61-1.91) that could not be explained by perinatal factors previously associated with the disease.CONCLUSIONS: We confirm that female sex is causally associated with childhood coeliac disease, but the reasons remains unknown.
KW - Causality
KW - Celiac Disease/epidemiology
KW - Female
KW - Humans
KW - Infant
KW - Male
KW - Proportional Hazards Models
KW - Regression Analysis
KW - Risk Factors
KW - Sex Factors
KW - Siblings
KW - Sweden/epidemiology
U2 - 10.1016/j.dld.2012.06.016
DO - 10.1016/j.dld.2012.06.016
M3 - Journal article
C2 - 22824835
VL - 44
SP - 909
EP - 913
JO - Rendiconti di Gastro-Enterologia
JF - Rendiconti di Gastro-Enterologia
SN - 1590-8658
IS - 11
ER -
ID: 364862820