Sex differences across developmental domains among children with a familial risk of severe mental disorders
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Sex differences across developmental domains among children with a familial risk of severe mental disorders. / Burton, Birgitte Klee; Andersen, Klaus Kaae; Greve, Aja N.; Hemager, Nicoline; Spang, Katrine S.; Ellersgaard, Ditte; Christiani, Camilla J.; Gantriis, Ditte; Gregersen, Maja; Søndergaard, Anne; Jepsen, Jens Richardt M.; Bliksted, Vibeke Fuglsang; Mors, Ole; Plessen, Kerstin Jessica; Nordentoft, Merete; Thorup, Anne A. E.
In: Psychological Medicine, Vol. 53, No. 8, 2023, p. 3628-3643.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Sex differences across developmental domains among children with a familial risk of severe mental disorders
AU - Burton, Birgitte Klee
AU - Andersen, Klaus Kaae
AU - Greve, Aja N.
AU - Hemager, Nicoline
AU - Spang, Katrine S.
AU - Ellersgaard, Ditte
AU - Christiani, Camilla J.
AU - Gantriis, Ditte
AU - Gregersen, Maja
AU - Søndergaard, Anne
AU - Jepsen, Jens Richardt M.
AU - Bliksted, Vibeke Fuglsang
AU - Mors, Ole
AU - Plessen, Kerstin Jessica
AU - Nordentoft, Merete
AU - Thorup, Anne A. E.
PY - 2023
Y1 - 2023
N2 - Background Sex differences in brain structure and neurodevelopment occur in non-clinical populations. We investigated whether sex had a similar effect on developmental domains amongst boys and girls with a familial risk of schizophrenia (FHR-SZ), bipolar disorder (FHR-BP), and controls. Methods Through Danish registries, we identified 522 7-year-old children (242 girls) with FHR-SZ, FHR-BP, and controls. We assessed their performance within the domains of neurocognition, motor function, language, social cognition, social behavior, psychopathology, and home environment. Results FHR-SZ boys compared with FHR-SZ girls had a higher proportion of disruptive behavior and attention-deficit hyperactivity disorder (ADHD) and exhibited lower performance in manual dexterity, balance, and emotion recognition. No sex differences were found between boys and girls within FHR-BP group. Compared with controls, both FHR-SZ boys and FHR-SZ girls showed impaired processing speed and working memory, had lower levels of global functioning, and were more likely to live in an inadequate home environment. Compared with control boys, FHR-SZ boys showed impaired manual dexterity, social behavior, and social responsiveness, and had a higher proportion of ADHD and disruptive behavior disorder diagnoses. Stress and adjustment disorders were more common in FHR-BP boys compared with control boys. We found no differences between FHR-BP girls and control girls. Conclusions Impairment within neurodevelopmental domains associated within FHR-SZ boys v. FHR-SZ girls was most evident among boys, whereas no sex differences were found within the FHR-BP group (FHR-BP boys v. FHR-BP girls). FHR-SZ boys exhibited the highest proportion of early developmental impairments.
AB - Background Sex differences in brain structure and neurodevelopment occur in non-clinical populations. We investigated whether sex had a similar effect on developmental domains amongst boys and girls with a familial risk of schizophrenia (FHR-SZ), bipolar disorder (FHR-BP), and controls. Methods Through Danish registries, we identified 522 7-year-old children (242 girls) with FHR-SZ, FHR-BP, and controls. We assessed their performance within the domains of neurocognition, motor function, language, social cognition, social behavior, psychopathology, and home environment. Results FHR-SZ boys compared with FHR-SZ girls had a higher proportion of disruptive behavior and attention-deficit hyperactivity disorder (ADHD) and exhibited lower performance in manual dexterity, balance, and emotion recognition. No sex differences were found between boys and girls within FHR-BP group. Compared with controls, both FHR-SZ boys and FHR-SZ girls showed impaired processing speed and working memory, had lower levels of global functioning, and were more likely to live in an inadequate home environment. Compared with control boys, FHR-SZ boys showed impaired manual dexterity, social behavior, and social responsiveness, and had a higher proportion of ADHD and disruptive behavior disorder diagnoses. Stress and adjustment disorders were more common in FHR-BP boys compared with control boys. We found no differences between FHR-BP girls and control girls. Conclusions Impairment within neurodevelopmental domains associated within FHR-SZ boys v. FHR-SZ girls was most evident among boys, whereas no sex differences were found within the FHR-BP group (FHR-BP boys v. FHR-BP girls). FHR-SZ boys exhibited the highest proportion of early developmental impairments.
KW - Bipolar disorder
KW - motor
KW - neurocognition
KW - psychopathology
KW - schizophrenia
KW - sex
KW - MAJOR DEPRESSIVE DISORDER
KW - DANISH HIGH-RISK
KW - BIPOLAR DISORDER
KW - ADULT SCHIZOPHRENIA
KW - CHILDHOOD MALTREATMENT
KW - 7-YEAR-OLD CHILDREN
KW - BRAIN-DEVELOPMENT
KW - METAANALYSIS
KW - RESILIENCE
KW - ATTENTION
U2 - 10.1017/S0033291722000265
DO - 10.1017/S0033291722000265
M3 - Journal article
C2 - 35156599
VL - 53
SP - 3628
EP - 3643
JO - Psychological Medicine
JF - Psychological Medicine
SN - 0033-2917
IS - 8
ER -
ID: 316147004