Serum cytokine levels in Kleine-Levin syndrome
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Serum cytokine levels in Kleine-Levin syndrome. / Kornum, Birgitte Rahbek; Rico, Thomas; Lin, Ling; Huang, Yu-Shu; Arnulf, Isabelle; Jennum, Poul; Mignot, Emmanuel.
In: Sleep Medicine, Vol. 16, No. 8, 08.2015, p. 961-5.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Serum cytokine levels in Kleine-Levin syndrome
AU - Kornum, Birgitte Rahbek
AU - Rico, Thomas
AU - Lin, Ling
AU - Huang, Yu-Shu
AU - Arnulf, Isabelle
AU - Jennum, Poul
AU - Mignot, Emmanuel
N1 - Copyright © 2015 Elsevier B.V. All rights reserved.
PY - 2015/8
Y1 - 2015/8
N2 - OBJECTIVE: Kleine-Levin Syndrome (KLS) is a rare sleep disorder causing recurrent symptomatic episodes of severe hypersomnia, cognitive impairment, apathy, and derealization. These episodes are interspersed with long periods of normal sleep, cognition, and behavior. The pathogenesis of KLS is still unknown. The objective of this study was to determine serum cytokine levels in patients with KLS during and between episodes.PATIENTS/METHODS: Fifty-two typical KLS patients were included in the study of whom 17 patients donated blood samples both during and between episodes. Blood samples were collected in USA, France, and Taiwan in a clinical setting. Processing of the samples was performed at the Stanford Center for Sleep Sciences and Medicine.RESULTS: We did not observe any changes in serum cytokine levels during KLS episodes compared to between episodes. In a small cohort of asymptomatic KLS patients and age- and gender matched healthy controls (n = 8/group) whose blood samples were all collected and processed at the same day; asymptomatic KLS patients had significantly higher levels of serum sVCAM1 cytokine compared to healthy controls.CONCLUSION: These data suggest that KLS episodes are not accompanied by an abnormal systemic immune reaction.
AB - OBJECTIVE: Kleine-Levin Syndrome (KLS) is a rare sleep disorder causing recurrent symptomatic episodes of severe hypersomnia, cognitive impairment, apathy, and derealization. These episodes are interspersed with long periods of normal sleep, cognition, and behavior. The pathogenesis of KLS is still unknown. The objective of this study was to determine serum cytokine levels in patients with KLS during and between episodes.PATIENTS/METHODS: Fifty-two typical KLS patients were included in the study of whom 17 patients donated blood samples both during and between episodes. Blood samples were collected in USA, France, and Taiwan in a clinical setting. Processing of the samples was performed at the Stanford Center for Sleep Sciences and Medicine.RESULTS: We did not observe any changes in serum cytokine levels during KLS episodes compared to between episodes. In a small cohort of asymptomatic KLS patients and age- and gender matched healthy controls (n = 8/group) whose blood samples were all collected and processed at the same day; asymptomatic KLS patients had significantly higher levels of serum sVCAM1 cytokine compared to healthy controls.CONCLUSION: These data suggest that KLS episodes are not accompanied by an abnormal systemic immune reaction.
KW - Adolescent
KW - Adult
KW - Case-Control Studies
KW - Chemokines
KW - Cytokines
KW - Female
KW - Humans
KW - Interleukins
KW - Kleine-Levin Syndrome
KW - Male
KW - Middle Aged
KW - Young Adult
U2 - 10.1016/j.sleep.2015.02.540
DO - 10.1016/j.sleep.2015.02.540
M3 - Journal article
C2 - 26116465
VL - 16
SP - 961
EP - 965
JO - Sleep Medicine
JF - Sleep Medicine
SN - 1389-9457
IS - 8
ER -
ID: 162754090