Serotonin receptors involved in vasopressin and oxytocin secretion
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Serotonin receptors involved in vasopressin and oxytocin secretion. / Jørgensen, Henrik; Riis, M.; Knigge, U.; Kjær, A.; Warberg, J.
In: Journal of Neuroendocrinology, Vol. 15, No. 3, 01.03.2003, p. 242-249.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Serotonin receptors involved in vasopressin and oxytocin secretion
AU - Jørgensen, Henrik
AU - Riis, M.
AU - Knigge, U.
AU - Kjær, A.
AU - Warberg, J.
PY - 2003/3/1
Y1 - 2003/3/1
N2 - Serotonin (5-HT), 5-HT agonists, the 5-HT precursor 5-hydroxytryptophan, 5-HT-releasers and -reuptake inhibitors stimulate the release of vasopressin and oxytocin. We investigated the involvement of 5-HT receptors in the serotonergic regulation of vasopressin and oxytocin secretion. Vasopressin and oxytocin secretion was stimulated by 5-HT, the 5-HT1A+1B+5A+7 agonist 5-carboxamidotryptamine (5-CT), the 5-HT2A+2C agonist DOI, the 5-HT2C+2A agonist mCPP, the 5-HT2C agonist MK-212, the 5-HT3 agonist SR 57277 and the 5-HT4 agonist RS 67506. The 5-HT1A agonist 8-OH-DPAT, which had no effect on vasopressin secretion, stimulated oxytocin secretion. The 5-HT-induced release of vasopressin and oxytocin was inhibited by central infusion of the 5-HT antagonists WAY 100635 (5-HT1A), LY 53857 (5-HT2A+2C), ICS 205-930 (5-HT3+4) and RS 23597 (5-HT4). The 5-HT2+6+7 antagonist metergoline in combination with the 5-HT1A+2+7 antagonist methysergide inhibited the stimulatory effect of 5-CT on both hormones, whereas the 5-HT1A+1B antagonist cyanopindolol only inhibited the oxytocin response. The 5-HT2A antagonist 4-(4-flourobenzoyl)-1-(4-phenylbutyl)-piperidine oxalate had no effect on DOI-induced hormone response. The 5-HT2C antagonist Y 25130 partly inhibited the stimulating effect of MK-212. ICS 205-930 and RS 23597 inhibited vasopressin and oxytocin secretion induced by RS 67506. WAY 100635 inhibited 8-OH-DPAT-induced oxytocin secretion. We conclude that 5-HT-induced vasopressin secretion primarily is mediated via 5-HT2C, 5-HT4 and 5-HT7 receptors, whereas 5-HT2A, 5-HT3 and 5-HT5A receptors seem to be of minor importance. 5-HT-induced oxytocin secretion involves 5-HT1A, 5-HT2C and 5-HT4 receptors; in addition an involvement of 5-HT1B, 5-HT5A and 5-HT7 receptors seems likely, whereas 5-HT2A and 5-HT3 receptors seem to be less important.
AB - Serotonin (5-HT), 5-HT agonists, the 5-HT precursor 5-hydroxytryptophan, 5-HT-releasers and -reuptake inhibitors stimulate the release of vasopressin and oxytocin. We investigated the involvement of 5-HT receptors in the serotonergic regulation of vasopressin and oxytocin secretion. Vasopressin and oxytocin secretion was stimulated by 5-HT, the 5-HT1A+1B+5A+7 agonist 5-carboxamidotryptamine (5-CT), the 5-HT2A+2C agonist DOI, the 5-HT2C+2A agonist mCPP, the 5-HT2C agonist MK-212, the 5-HT3 agonist SR 57277 and the 5-HT4 agonist RS 67506. The 5-HT1A agonist 8-OH-DPAT, which had no effect on vasopressin secretion, stimulated oxytocin secretion. The 5-HT-induced release of vasopressin and oxytocin was inhibited by central infusion of the 5-HT antagonists WAY 100635 (5-HT1A), LY 53857 (5-HT2A+2C), ICS 205-930 (5-HT3+4) and RS 23597 (5-HT4). The 5-HT2+6+7 antagonist metergoline in combination with the 5-HT1A+2+7 antagonist methysergide inhibited the stimulatory effect of 5-CT on both hormones, whereas the 5-HT1A+1B antagonist cyanopindolol only inhibited the oxytocin response. The 5-HT2A antagonist 4-(4-flourobenzoyl)-1-(4-phenylbutyl)-piperidine oxalate had no effect on DOI-induced hormone response. The 5-HT2C antagonist Y 25130 partly inhibited the stimulating effect of MK-212. ICS 205-930 and RS 23597 inhibited vasopressin and oxytocin secretion induced by RS 67506. WAY 100635 inhibited 8-OH-DPAT-induced oxytocin secretion. We conclude that 5-HT-induced vasopressin secretion primarily is mediated via 5-HT2C, 5-HT4 and 5-HT7 receptors, whereas 5-HT2A, 5-HT3 and 5-HT5A receptors seem to be of minor importance. 5-HT-induced oxytocin secretion involves 5-HT1A, 5-HT2C and 5-HT4 receptors; in addition an involvement of 5-HT1B, 5-HT5A and 5-HT7 receptors seems likely, whereas 5-HT2A and 5-HT3 receptors seem to be less important.
KW - 5-HT-receptor
KW - 5-HT
KW - 5-HT receptor
KW - Neuroendocrine regulation
KW - Oxytocin
KW - Serotonin
KW - Vasopressin
UR - http://www.scopus.com/inward/record.url?scp=0037373005&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2826.2003.00978.x
DO - 10.1046/j.1365-2826.2003.00978.x
M3 - Review
C2 - 12588512
AN - SCOPUS:0037373005
VL - 15
SP - 242
EP - 249
JO - Journal of Neuroendocrinology
JF - Journal of Neuroendocrinology
SN - 0953-8194
IS - 3
ER -
ID: 283515050