Semantic memory impairment in the earliest phases of Alzheimer's disease
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Semantic memory impairment in the earliest phases of Alzheimer's disease. / Vogel, Asmus; Gade, Anders; Stokholm, Jette; Waldemar, Gunhild.
In: Dementia and Geriatric Cognitive Disorders, Vol. 19, No. 2-3, 2005, p. 75-81.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Semantic memory impairment in the earliest phases of Alzheimer's disease
AU - Vogel, Asmus
AU - Gade, Anders
AU - Stokholm, Jette
AU - Waldemar, Gunhild
PY - 2005
Y1 - 2005
N2 - The presence and the nature of semantic memory dysfunction in Alzheimer's disease (AD) have been widely debated. This study aimed to determine the frequency of impaired semantic test performances in mild AD and to study whether incipient semantic impairments could be identified in predementia AD. Five short neuropsychological tests sensitive to semantic memory and easily applicable in routine practice were administered to 102 patients with mild AD (Mini-Mental State Examination score above 19), 22 predementia AD patients and 58 healthy subjects. 'Category fluency' and 'naming of famous faces' were the most frequently impaired tests in both patient groups. The study demonstrated that impairments on semantically related tests are common in mild AD and may exist prior to the clinical diagnosis. The results imply that assessment of semantic memory is relevant in the evaluation of patients with suspected AD.
AB - The presence and the nature of semantic memory dysfunction in Alzheimer's disease (AD) have been widely debated. This study aimed to determine the frequency of impaired semantic test performances in mild AD and to study whether incipient semantic impairments could be identified in predementia AD. Five short neuropsychological tests sensitive to semantic memory and easily applicable in routine practice were administered to 102 patients with mild AD (Mini-Mental State Examination score above 19), 22 predementia AD patients and 58 healthy subjects. 'Category fluency' and 'naming of famous faces' were the most frequently impaired tests in both patient groups. The study demonstrated that impairments on semantically related tests are common in mild AD and may exist prior to the clinical diagnosis. The results imply that assessment of semantic memory is relevant in the evaluation of patients with suspected AD.
U2 - http://dx.doi.org/10.1159/000082352
DO - http://dx.doi.org/10.1159/000082352
M3 - Journal article
VL - 19
SP - 75
EP - 81
JO - Dementia and Geriatric Cognitive Disorders
JF - Dementia and Geriatric Cognitive Disorders
SN - 1420-8008
IS - 2-3
ER -
ID: 103922