Seasonal light hours modulate peripheral clocks and energy metabolism in mice
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Seasonal light hours modulate peripheral clocks and energy metabolism in mice. / Small, Lewin; Lundell, Leonidas S.; Iversen, Jo; Ehrlich, Amy M.; Dall, Morten; Basse, Astrid L.; Dalbram, Emilie; Hansen, Ann N.; Treebak, Jonas T.; Barrès, Romain; Zierath, Juleen R.
In: Cell Metabolism, Vol. 35, No. 10, 2023, p. 1722-1735.e5.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Seasonal light hours modulate peripheral clocks and energy metabolism in mice
AU - Small, Lewin
AU - Lundell, Leonidas S.
AU - Iversen, Jo
AU - Ehrlich, Amy M.
AU - Dall, Morten
AU - Basse, Astrid L.
AU - Dalbram, Emilie
AU - Hansen, Ann N.
AU - Treebak, Jonas T.
AU - Barrès, Romain
AU - Zierath, Juleen R.
N1 - Publisher Copyright: © 2023 The Authors
PY - 2023
Y1 - 2023
N2 - Except for latitudes close to the equator, seasonal variation in light hours can change dramatically between summer and winter. Yet investigations into the interplay between energy metabolism and circadian rhythms typically use a 12 h light:12 h dark photoperiod corresponding to the light duration at the equator. We hypothesized that altering the seasonal photoperiod affects both the rhythmicity of peripheral tissue clocks and energy homeostasis. Mice were housed at photoperiods representing either light hours in summer, winter, or the equinox. Mice housed at a winter photoperiod exhibited an increase in the amplitude of rhythmic lipid metabolism and a modest reduction in fat mass and liver triglyceride content. Comparing melatonin-proficient and -deficient mice, the effect of seasonal light on energy metabolism was largely driven by differences in the rhythmicity of food intake and not melatonin. Together, these data indicate that seasonal light impacts energy metabolism by modulating the timing of eating.
AB - Except for latitudes close to the equator, seasonal variation in light hours can change dramatically between summer and winter. Yet investigations into the interplay between energy metabolism and circadian rhythms typically use a 12 h light:12 h dark photoperiod corresponding to the light duration at the equator. We hypothesized that altering the seasonal photoperiod affects both the rhythmicity of peripheral tissue clocks and energy homeostasis. Mice were housed at photoperiods representing either light hours in summer, winter, or the equinox. Mice housed at a winter photoperiod exhibited an increase in the amplitude of rhythmic lipid metabolism and a modest reduction in fat mass and liver triglyceride content. Comparing melatonin-proficient and -deficient mice, the effect of seasonal light on energy metabolism was largely driven by differences in the rhythmicity of food intake and not melatonin. Together, these data indicate that seasonal light impacts energy metabolism by modulating the timing of eating.
KW - circadian biology
KW - energy homeostasis
KW - glucose metabolism
KW - hormones
KW - integrative physiology
KW - obesity
KW - transcriptomics
U2 - 10.1016/j.cmet.2023.08.005
DO - 10.1016/j.cmet.2023.08.005
M3 - Journal article
C2 - 37689069
AN - SCOPUS:85173590530
VL - 35
SP - 1722-1735.e5
JO - Cell Metabolism
JF - Cell Metabolism
SN - 1550-4131
IS - 10
ER -
ID: 371655598