Screening for Y microdeletions in men with testicular cancer and undescended testis

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Screening for Y microdeletions in men with testicular cancer and undescended testis. / Bor, Pinar; Hindkjaer, Johnny; Kølvraa, Steen; Rossen, Philip; von der Maase, Hans; Jørgensen, Troels Munch; Sørensen, Viggo Tønning; Eiberg, Hans; Ingerslev, Hans Jakob.

In: Journal of Assisted Reproduction and Genetics, Vol. 23, No. 1, 2006, p. 41-45.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bor, P, Hindkjaer, J, Kølvraa, S, Rossen, P, von der Maase, H, Jørgensen, TM, Sørensen, VT, Eiberg, H & Ingerslev, HJ 2006, 'Screening for Y microdeletions in men with testicular cancer and undescended testis', Journal of Assisted Reproduction and Genetics, vol. 23, no. 1, pp. 41-45. https://doi.org/10.1007/s10815-005-9001-5

APA

Bor, P., Hindkjaer, J., Kølvraa, S., Rossen, P., von der Maase, H., Jørgensen, T. M., Sørensen, V. T., Eiberg, H., & Ingerslev, H. J. (2006). Screening for Y microdeletions in men with testicular cancer and undescended testis. Journal of Assisted Reproduction and Genetics, 23(1), 41-45. https://doi.org/10.1007/s10815-005-9001-5

Vancouver

Bor P, Hindkjaer J, Kølvraa S, Rossen P, von der Maase H, Jørgensen TM et al. Screening for Y microdeletions in men with testicular cancer and undescended testis. Journal of Assisted Reproduction and Genetics. 2006;23(1):41-45. https://doi.org/10.1007/s10815-005-9001-5

Author

Bor, Pinar ; Hindkjaer, Johnny ; Kølvraa, Steen ; Rossen, Philip ; von der Maase, Hans ; Jørgensen, Troels Munch ; Sørensen, Viggo Tønning ; Eiberg, Hans ; Ingerslev, Hans Jakob. / Screening for Y microdeletions in men with testicular cancer and undescended testis. In: Journal of Assisted Reproduction and Genetics. 2006 ; Vol. 23, No. 1. pp. 41-45.

Bibtex

@article{ca67fbb070eb11dcbee902004c4f4f50,
title = "Screening for Y microdeletions in men with testicular cancer and undescended testis",
abstract = "PURPOSE: To investigate a possible association between testicular cancer or undescended testis and Y microdeletions. METHODS: It was designed as a retrospective clinical study. A total of 225 men with testicular cancer or undescended testis were included to study. Fertile men (n = 200) were investigated as a control. Genomic DNA, which was extracted from blood samples were investigated with a fluorescent multiplex PCR protocol for screening for Y microdeletions. RESULTS: A single STS missing was found in eight men; one from the control group (sY153), seven from the patients group. The positive cases showed a single STS missing of marker sY153 and sY139 in testicular cancer (6/185) and undescended testis (1/40) patients, respectively. CONCLUSIONS: Since no contiguous, real Y microdeletions were found in the study population, it seems that Y microdeletions are not a likely common etiological cause of poor spermatogenesis in testicular cancer and undescended testis. However, it remains to be determined whether men having a single STS missing have a risk of developing testis cancer or having undescended testis.",
author = "Pinar Bor and Johnny Hindkjaer and Steen K{\o}lvraa and Philip Rossen and {von der Maase}, Hans and J{\o}rgensen, {Troels Munch} and S{\o}rensen, {Viggo T{\o}nning} and Hans Eiberg and Ingerslev, {Hans Jakob}",
note = "Keywords: Adult; Chromosome Deletion; Chromosomes, Human, Y; Cryptorchidism; Genetic Testing; Humans; Male; Middle Aged; Testicular Neoplasms",
year = "2006",
doi = "10.1007/s10815-005-9001-5",
language = "English",
volume = "23",
pages = "41--45",
journal = "Journal of Assisted Reproduction and Genetics",
issn = "1058-0468",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - Screening for Y microdeletions in men with testicular cancer and undescended testis

AU - Bor, Pinar

AU - Hindkjaer, Johnny

AU - Kølvraa, Steen

AU - Rossen, Philip

AU - von der Maase, Hans

AU - Jørgensen, Troels Munch

AU - Sørensen, Viggo Tønning

AU - Eiberg, Hans

AU - Ingerslev, Hans Jakob

N1 - Keywords: Adult; Chromosome Deletion; Chromosomes, Human, Y; Cryptorchidism; Genetic Testing; Humans; Male; Middle Aged; Testicular Neoplasms

PY - 2006

Y1 - 2006

N2 - PURPOSE: To investigate a possible association between testicular cancer or undescended testis and Y microdeletions. METHODS: It was designed as a retrospective clinical study. A total of 225 men with testicular cancer or undescended testis were included to study. Fertile men (n = 200) were investigated as a control. Genomic DNA, which was extracted from blood samples were investigated with a fluorescent multiplex PCR protocol for screening for Y microdeletions. RESULTS: A single STS missing was found in eight men; one from the control group (sY153), seven from the patients group. The positive cases showed a single STS missing of marker sY153 and sY139 in testicular cancer (6/185) and undescended testis (1/40) patients, respectively. CONCLUSIONS: Since no contiguous, real Y microdeletions were found in the study population, it seems that Y microdeletions are not a likely common etiological cause of poor spermatogenesis in testicular cancer and undescended testis. However, it remains to be determined whether men having a single STS missing have a risk of developing testis cancer or having undescended testis.

AB - PURPOSE: To investigate a possible association between testicular cancer or undescended testis and Y microdeletions. METHODS: It was designed as a retrospective clinical study. A total of 225 men with testicular cancer or undescended testis were included to study. Fertile men (n = 200) were investigated as a control. Genomic DNA, which was extracted from blood samples were investigated with a fluorescent multiplex PCR protocol for screening for Y microdeletions. RESULTS: A single STS missing was found in eight men; one from the control group (sY153), seven from the patients group. The positive cases showed a single STS missing of marker sY153 and sY139 in testicular cancer (6/185) and undescended testis (1/40) patients, respectively. CONCLUSIONS: Since no contiguous, real Y microdeletions were found in the study population, it seems that Y microdeletions are not a likely common etiological cause of poor spermatogenesis in testicular cancer and undescended testis. However, it remains to be determined whether men having a single STS missing have a risk of developing testis cancer or having undescended testis.

U2 - 10.1007/s10815-005-9001-5

DO - 10.1007/s10815-005-9001-5

M3 - Journal article

C2 - 16550456

VL - 23

SP - 41

EP - 45

JO - Journal of Assisted Reproduction and Genetics

JF - Journal of Assisted Reproduction and Genetics

SN - 1058-0468

IS - 1

ER -

ID: 1199204