Screening for retinopathy in children with type 1 diabetes in Denmark
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Screening for retinopathy in children with type 1 diabetes in Denmark. / Herskin, Camilla W.; Olsen, Birthe S.; Madsen, Mette; Kjærsgaard, Per; Fredheim, Siri; Johansen, Anders; Kristensen, Kurt; Birkebæk, Niels H.; Svensson, Jannet; Pilgaard, Kasper A.; Johannesen, Jesper.
In: Pediatric Diabetes, Vol. 21, No. 1, 2020, p. 106-111.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Screening for retinopathy in children with type 1 diabetes in Denmark
AU - Herskin, Camilla W.
AU - Olsen, Birthe S.
AU - Madsen, Mette
AU - Kjærsgaard, Per
AU - Fredheim, Siri
AU - Johansen, Anders
AU - Kristensen, Kurt
AU - Birkebæk, Niels H.
AU - Svensson, Jannet
AU - Pilgaard, Kasper A.
AU - Johannesen, Jesper
PY - 2020
Y1 - 2020
N2 - Background/Objective: Children with type 1 diabetes (T1D) are screened regularly for retinopathy with fundus photography to prevent visual impairment. According to Danish national guidelines, screening should take place at age 12, 15, and 18 years after minimum 3 years of diabetes. As glycemic control has improved, prevalence of retinopathy is expected to be decreased. The aim of this study is to investigate the prevalence, degree, and progression of retinopathy in children with T1D and to explore if screening at 12 years is currently indicated in Denmark. Methods: Data on all Danish children with onset of T1D from 2003 to 2013 (n = 2943) were collected from the “DanDiabKids” registry. For children with registered screenings (n = 2382), prevalence of retinopathy at 12, 15, and 18 years was determined. In children with retinopathy, subsequent screenings were studied to reveal if retinopathy was persistent or temporary. Results: Prevalence of retinopathy at 12, 15, and 18 years was 0.9%, 2.3%, and 3.1%, respectively. Minimal background retinopathy was seen in over 90% and 100% at 12 years. In available re-screenings, retinopathy resolved spontaneously in 87.5% of all cases and 100% of cases at 12 years. Conclusions: The prevalence of retinopathy in Danish children with T1D was low. At 12 years, prevalence was 0.9% and exclusively minimal background retinopathy with 100% remission in re-screenings. Thus, screening at this age does not seem to have significant clinical relevance. We propose more individualized screening selection before the age of 15.
AB - Background/Objective: Children with type 1 diabetes (T1D) are screened regularly for retinopathy with fundus photography to prevent visual impairment. According to Danish national guidelines, screening should take place at age 12, 15, and 18 years after minimum 3 years of diabetes. As glycemic control has improved, prevalence of retinopathy is expected to be decreased. The aim of this study is to investigate the prevalence, degree, and progression of retinopathy in children with T1D and to explore if screening at 12 years is currently indicated in Denmark. Methods: Data on all Danish children with onset of T1D from 2003 to 2013 (n = 2943) were collected from the “DanDiabKids” registry. For children with registered screenings (n = 2382), prevalence of retinopathy at 12, 15, and 18 years was determined. In children with retinopathy, subsequent screenings were studied to reveal if retinopathy was persistent or temporary. Results: Prevalence of retinopathy at 12, 15, and 18 years was 0.9%, 2.3%, and 3.1%, respectively. Minimal background retinopathy was seen in over 90% and 100% at 12 years. In available re-screenings, retinopathy resolved spontaneously in 87.5% of all cases and 100% of cases at 12 years. Conclusions: The prevalence of retinopathy in Danish children with T1D was low. At 12 years, prevalence was 0.9% and exclusively minimal background retinopathy with 100% remission in re-screenings. Thus, screening at this age does not seem to have significant clinical relevance. We propose more individualized screening selection before the age of 15.
KW - adolescents
KW - children
KW - diabetes
KW - retinopathy
U2 - 10.1111/pedi.12936
DO - 10.1111/pedi.12936
M3 - Journal article
C2 - 31618523
AN - SCOPUS:85074616784
VL - 21
SP - 106
EP - 111
JO - Pediatric Diabetes
JF - Pediatric Diabetes
SN - 1399-543X
IS - 1
ER -
ID: 236218986