Role of protein dynamics in transmembrane receptor signalling
Research output: Contribution to journal › Review › Research › peer-review
Standard
Role of protein dynamics in transmembrane receptor signalling. / Wang, Yong; Bugge, Katrine Østergaard; Kragelund, Birthe Brandt; Lindorff-Larsen, Kresten.
In: Current Opinion in Structural Biology, Vol. 48, 2018, p. 74-82.Research output: Contribution to journal › Review › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Role of protein dynamics in transmembrane receptor signalling
AU - Wang, Yong
AU - Bugge, Katrine Østergaard
AU - Kragelund, Birthe Brandt
AU - Lindorff-Larsen, Kresten
N1 - Copyright © 2017 Elsevier Ltd. All rights reserved.
PY - 2018
Y1 - 2018
N2 - Cells are dependent on transmembrane receptors to communicate and transform chemical and physical signals into intracellular responses. Because receptors transport 'information', conformational changes and protein dynamics play a key mechanistic role. We here review examples where experiment and computation have been used to study receptor dynamics. Recent studies on three distinct classes of receptors (G-protein coupled receptors, ligand-gated ion-channels and single-pass receptors) are highlighted to show that conformational changes across a range of time-scales and length-scales are central to function. Because the receptors function in a heterogeneous environment and need to be able to switch between distinct functional states, they may be particularly sensitive to small perturbations that complicate studies linking dynamics to function.
AB - Cells are dependent on transmembrane receptors to communicate and transform chemical and physical signals into intracellular responses. Because receptors transport 'information', conformational changes and protein dynamics play a key mechanistic role. We here review examples where experiment and computation have been used to study receptor dynamics. Recent studies on three distinct classes of receptors (G-protein coupled receptors, ligand-gated ion-channels and single-pass receptors) are highlighted to show that conformational changes across a range of time-scales and length-scales are central to function. Because the receptors function in a heterogeneous environment and need to be able to switch between distinct functional states, they may be particularly sensitive to small perturbations that complicate studies linking dynamics to function.
KW - Journal Article
KW - Review
U2 - 10.1016/j.sbi.2017.10.017
DO - 10.1016/j.sbi.2017.10.017
M3 - Review
C2 - 29136528
VL - 48
SP - 74
EP - 82
JO - Current Opinion in Structural Biology
JF - Current Opinion in Structural Biology
SN - 0959-440X
ER -
ID: 188260770