Risk of prolonged sedation with the use of chlordiazepoxide in alcohol withdrawal treatment
Research output: Contribution to journal › Review › Research › peer-review
SummaryThe use of chlordiazepoxide in the treatment of alcohol withdrawal symptoms poses a risk of prolonged sedation with the need of weeks lasting antidote treatment, and extended hospitalization due to active metabolites with very long half-lives.We present four case stories to elucidate this issue. One patient received 800 mg chlordiazepoxide and was treated with flumazenil for 42 days. Another patient was treated with 100 mg chlordiazepoxide. 5 days after administration of chlordiazepoxide, concentrations of chlordiazepoxide and its active metabolite demoxepam, were within therapeutic range, the patient was treated with flumazenil for 6 days. He died after palliative care.The great individual variation in the clinical effect of chlordiazepoxide depends on the activity of the CYP P450 system, especially CYP3A4/A5 and CYPS2C19, which can be impaired in cirrhotic and elderly patients.
Original language | English |
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Journal | Adverse Drug Reaction Bulletin |
Volume | 340 |
Issue number | 1 |
Pages (from-to) | 1319-1322 |
Number of pages | 4 |
ISSN | 0044-6394 |
DOIs | |
Publication status | Published - 1 Jun 2023 |
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ID: 368254628